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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 447 - 457 (11page)
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초록· 키워드
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Objective To evaluate the safety and potential efficacy of “recombinant human growth hormone (rhGH)” on the functional recovery of completed stroke patients.Method Completed stroke patients were recruited. All participants were randomly assigned to the GH group (rhGH injection and rehabilitative therapy) or the control group (only rehabilitative therapy). Above all, they were closely monitored for safety. Further, for the efficacy measurement, Korean Modified Barthel Index (K-MBI), Manual Muscle strength Test (MMT), and Fugl-Meyer assessment (FMA) were assessed to determine the changes of functional recovery during 6-months of the study period. Along with it, diffusion tensor image was taken as the baseline, and a followed-up study to observe the changes in diffusion tensor tractography (DTT), during the period, and one patient in the GH group was also examined with functional MRI (fMRI). Index of fatigue on 5 point scale for the study period was also assessed.Results Twenty-two patients were enrolled, and 15 completed the study and were included in the analysis. No harmful adverse events were observed in the GH group. By comparison between the groups, the GH group showed more improvement in K-MBI than the control group (p<0.05). DTT showed less decrement of fibers in the GH group than in the control group, without statistical significance. fMRI showed an increment in the activated area. Patients in the GH group expressed no fatigue at all, during the study period (p=0.00).Conclusion The administration of rhGH in long term resulted in the improvement in K-MBI, and subjectively less tiredness during the injection period.
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참고문헌 (23)
참고문헌 신청
Bach LA / 2004 / The insulin-like growth factor system: towards
Bath KG / 2010 / Neurotrophic factor control of adult SVZ neurogenesis / Dev Neurobiol 70 : 339 ~ 349
Beilharz EJ / 1998 / Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury / Brain Res Mol
Cramer SC / 2008 / Neuroplasticity and brain repair after stroke / Curr Opin Neurol 21 : 76 ~ 82
Delaney CL / 2001 / Insulin- like growth factor-I and over-expression of BclxL prevent glucose-mediated apoptosis in Schwann cells / J Neuropathol Exp Neurol 60 : 147 ~ 160
Bath KG / 2010 / Neurotrophic factor control of adult SVZ neurogenesis / Dev Neurobiol 70 : 339 ~ 349
Beilharz EJ / 1998 / Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury / Brain Res Mol
Cramer SC / 2008 / Neuroplasticity and brain repair after stroke / Curr Opin Neurol 21 : 76 ~ 82
Delaney CL / 2001 / Insulin- like growth factor-I and over-expression of BclxL prevent glucose-mediated apoptosis in Schwann cells / J Neuropathol Exp Neurol 60 : 147 ~ 160
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