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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 515 - 522 (8page)
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초록· 키워드
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Cell mediated immune responses play a prominent role in syphilis, which is caused by Treponema pallidum. The role of dendritic cells (DC) in the syphilitic infection is not well understood in human. In the present study, we studied interaction of T. pallidum with DC, generated from human peripheral blood mononuclear cells with GM-CSF and IL-4. After adding T. pallidum for 16 hours to immature DC at culture day 7, the change of surface antigens on DC was monitored by flow cytometry, the amount of IL-12 in culture supernatant of DC was measured by ELISA and T cell stimulatory capacity of DC was checked in mixed lymphocyte reaction (MLR). We have observed an efficient phagocytosis of T. pallidum by electron microscopy as early as 2 hours after addition of T. pallidum to DC. Interaction of DC with T. pallidum resulted in increased surface expression of CD83 which was proportionally increased according to the number of T. pallidum. Expressions of CD80, CD86 and HLA-DR on DC were slightly increased. The amount of IL-12 in the culture supernatant of DC was increased (1,099pg/ml) after the addition of T. pallidum. T. pallidum-infected DC also displayed enhanced T cell stimulatory capacity in MLR. As seen from the above, we observed phagocytosis of T. pallidum by DC as early as 2 hours after addition of T. pallidum to DC and found that T. pallidum can stimulate DC maturation which mean that DC modulate an protective immune response during T. pallidum infection.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
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/ 1982 / Murine monoclonal antibodies specific for virulent Treponema pallidum (Nichols) 36 : 1076 ~ 1085
/ 1993 / Scintigraphic diagnosis of syphilitic lesions in rabbits by radiolabelled monoclonal antibodies specific for Treponema pallidum 73 : 276 ~ 279
/ 1994 / Proliferating dendritic cell progenitors in human blood 180 : 83 ~ 93
/ 1995 / Maturation and migration of cutaneous dendritic cells 105 (1 suppl) : 2S ~ 7S
/ 1982 / Murine monoclonal antibodies specific for virulent Treponema pallidum (Nichols) 36 : 1076 ~ 1085
/ 1993 / Scintigraphic diagnosis of syphilitic lesions in rabbits by radiolabelled monoclonal antibodies specific for Treponema pallidum 73 : 276 ~ 279
/ 1994 / Proliferating dendritic cell progenitors in human blood 180 : 83 ~ 93
/ 1995 / Maturation and migration of cutaneous dendritic cells 105 (1 suppl) : 2S ~ 7S
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