지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 163 - 170 (8page)
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초록· 키워드
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Purpose: We evaluated 5 different rat models using different agents in order to establish a standard animal model for interstitial cystitis (IC) in terms of the functional and pathologic characteristics of the bladder.
Methods: Five IC models were generated in 8-week-old female Sprague-Dawley rats via transurethral instillation of 0.1M hydrogen chloride (HCl) or 3% acetic acid (AA), intraperitoneal injection of cyclophosphamide (CYP) or lipopolysaccharide (LPS), or subcutaneous injection of uroplakin II (UPK2). After generating the IC models, conscious cystometry was performed on days 3, 7, and 14. All rats were euthanized on day 14 and their bladders were obtained for histological and pro-inflammatory- related gene expression analysis.
Results: In the cystometric analysis, all experimental groups showed significantly decreased intercontraction intervals compared with the control group on day 3, but only the LPS and UPK groups maintained significantly shorter intercontraction intervals than the control group on day 14. The histological analysis revealed that areas with severe urothelial erosion (HCl, AA, and UPK) and hyperplasia (CYP and LPS), particularly in the UPK-treated bladders, showed a markedly increased infiltration of toluidine blue-stained mast cells and increased tissue fibrosis. In addition, significantly elevated expression of interleukin- 1b, interleukin-6, myeloperoxidase, monocyte chemotactic protein 1, and Toll-like receptors 2 and 4 was observed in the UPK group compared to the other groups.
Conclusions: Among the 5 different agents, the injection of UPK generated the most effective IC animal model, showing consequent urothelial barrier loss, inflammatory reaction, tissue fibrosis stimulation, and persistent hyperactive bladder.
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참고문헌 (28)
참고문헌 신청
Keay S / 1997 / Urine autoantibodies in interstitial cystitis / J Urol 157:1083~1087
Ochs RL / 1997 / Autoantibodies and interstitial cystitis / Clin Lab Med 17:571~579
van de Merwe JP / 2007 / Interstitial cystitis and systemic autoimmune diseases / Nat Clin Pract Urol 4:484~491
Lorenzo Gómez MF / 2004 / Physiopathologic relationship between interstitial cystitis and rheumatic, autoimmune, and chronic inflammatory diseases / Arch Esp Urol 57:25~34
Adamowicz J / 2014 / Conditioned medium derived from mesenchymal stem cells culture as a intravesical therapy for cystitis interstitials / Med Hypotheses 82 : 670 ~ 673
Ochs RL / 1997 / Autoantibodies and interstitial cystitis / Clin Lab Med 17:571~579
van de Merwe JP / 2007 / Interstitial cystitis and systemic autoimmune diseases / Nat Clin Pract Urol 4:484~491
Lorenzo Gómez MF / 2004 / Physiopathologic relationship between interstitial cystitis and rheumatic, autoimmune, and chronic inflammatory diseases / Arch Esp Urol 57:25~34
Adamowicz J / 2014 / Conditioned medium derived from mesenchymal stem cells culture as a intravesical therapy for cystitis interstitials / Med Hypotheses 82 : 670 ~ 673
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