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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 158 - 163 (6page)
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Purpose: The aim of this study was to evaluate changes in expressions of neuregulin (NRG)1 and erbB2 tyrosine kinase (ErbB2) in bladders of rats with cyclophosphamide (CYP)-induced interstitial cystitis (IC).
Methods: Twenty-four Sprague-Dawley rats were divided into the IC group (n=16) and the control group (n=8). After inducing IC with intraperitoneal CYP injection, expressions of NRG1 and ErbB2 were analyzed using western blotting and reverse transcriptase-polymerase chain reaction.
Results: In Western blotting, relative intensities and distributions of both NRG1 and ErbB2 were approximately 1.5- and 3.2- fold higher, respectively, in the IC group than in the control group (mean±standard deviation: 1.42±0.09 vs. 0.93±0.15 and 0.93±0.16 vs. 0.29±0.08, P<0.05). In the rat bladder samples, mRNA expression levels of NRG1 and ErbB2 were higher in the IC group than in the control group (P<0.05).
Conclusions: Our study has demonstrated significant changes in mRNA expression and immunoreactivity of NRG1 and ErbB2 receptors in the urinary bladder after CYP-induced IC. These results suggest that the up-regulated NRG1 may play a role in inducing an overactive bladder and promoting regeneration in the inflammatory bladder with CYP-induced IC.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bade J / 2003 / Future research needs for the definition/ diagnosis of interstitial cystitis / Int J Urol (10Suppl) : S31 ~ S34
Calvo M / 2010 / Neuregulin- ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury / J Neurosci
Chan LK / 2015 / Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma / Oncotarget 6 : 20964 ~ 20
Cruz CD / 2007 / The ERK 1 and 2 pathway in the nervous system: from basic aspects to possible clinical applications in pain and visceral dysfunction / Curr Neuropharmacol 5
Davis NF / 2014 / Interstitial cystitis/painful bladder syndrome: epidemiology, pathophysiology and evidence-based treatment options / Eur J Obstet Gynecol Reprod Biol 175 :
Calvo M / 2010 / Neuregulin- ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury / J Neurosci
Chan LK / 2015 / Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma / Oncotarget 6 : 20964 ~ 20
Cruz CD / 2007 / The ERK 1 and 2 pathway in the nervous system: from basic aspects to possible clinical applications in pain and visceral dysfunction / Curr Neuropharmacol 5
Davis NF / 2014 / Interstitial cystitis/painful bladder syndrome: epidemiology, pathophysiology and evidence-based treatment options / Eur J Obstet Gynecol Reprod Biol 175 :
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