지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 213 - 219 (7page)
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초록· 키워드
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Purpose: Oxytocin is associated with the ability to form normal social attachments. c-Fos is an immediate early gene whose expression is used as a marker for stimulus-induced changes in neurons. The effect of phosphodiesterase-5 (PDE-5) inhibitors on oxytocin activation in the brain without sexual stimuli has not yet been reported. In the present study, we investigated the effects of vardenafil on oxytocin and c-Fos expression in the paraventricular nucleus (PVN) of conscious rats.
Methods: Male Sprague-Dawley rats weighing 300±10 g were divided into 6 groups (n=5 in each group): the control group, the 1-day-0.5 mg/kg, the 1-day-1 mg/kg, the 1-day-2 mg/kg, the 3-day-1 mg/kg, and the 7-day-1 mg/kg vardenafil administration group. The experiment was conducted without sexual stimulation. Vardenafil was orally administered. The animals in the control group received an equivalent amount of distilled water orally. The expression of oxytocin and c-Fos in the PVN was detected by immunohistochemistry.
Results: Oxytocin expression in the PVN was increased by 1 day administration of 2 mg/kg vardenafil, and this effect of vardenafil appeared in a duration-dependent manner. c-Fos in the oxytocin neurons of the PVN was increased by 1 day administration of 2 mg/kg vardenafil, and this effect of vardenafil also appeared in a duration-dependent manner. These results showed that vardenafil augments the expression of oxytocin with activation of oxytocin neurons in the PVN.
Conclusions: In this study, we showed that the PDE-5 inhibitor, vardenafil directly enhances oxytocin expression and also activates oxytocin neurons in the PVN, which indicates that vardenafil may exert positive effects on affiliation behavior and social interaction.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Young LJ / 1999 / Oxytocin and vasopressin receptors and species-typical social behaviors / Horm Behav 36:212~221
Gimpl G / 2001 / The oxytocin receptor system: structure,function, and regulation / Physiol Rev 81:629~683
Neumann ID / 2002 / Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis / Prog Brain Res 139:147~162
Lee PR / 2005 / Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin / Neuropsychopharmacology 30:1883~1894
Fries AB / 2005 / Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior / Proc Natl Acad Sci U S A 102:17237~17240
Gimpl G / 2001 / The oxytocin receptor system: structure,function, and regulation / Physiol Rev 81:629~683
Neumann ID / 2002 / Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis / Prog Brain Res 139:147~162
Lee PR / 2005 / Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin / Neuropsychopharmacology 30:1883~1894
Fries AB / 2005 / Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior / Proc Natl Acad Sci U S A 102:17237~17240
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