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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 117 - 125 (9page)
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This study was investigated the effects on the radical scavenging activities and hepatic lipid levels in rats fed a high-fat diet (HFD) by the 70% ethanolic extract from Rubus coreanus. The Rubus coreanus extract (RCE) was administered through the gastrointestinal tract at 150 mg/kg BW/day for 5 weeks (HFD+RCE). Total phenol content was 157.93 mg gallic acid/g in the RCE. Scavenging activities to DPPH, ABTS, an d hydroxyl radicals by RCE significantly increased in a does-dependent manner of 50∼500 g/mL concentration. DPPH and ABTS radical scavenging activities were over the 70% in the 500 g/mL concentration. During the five weeks study, the food efficiency ratio was no significant dif-ferences between the HFD and HFD+RCE. Liver weight of HFD+RCE (3.75 g/100 g BW) was sig-nificantly decreased compared to those of the HFD. Hepatic triglyceride and total cholesterol levels of HFD+RCE were significantly lower compared to those of the HFD. The hepatic TBARS contents in the HFD+RCE was significantly decreased to the HFD, radical scavenging activity was markedly in-creased in HFD+RCE as normal group. In histological observation of liver tissues, the hepatocytes of HFD+RCE appeared the reduced aspects on the size and numbers of lipid droplets in cytoplasm com-pared to the HFD. Our results suggest that RCE could have antioxidant activities and hepatic hypolipi-demic effects by its phenolic compounds.
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참고문헌 (41)
참고문헌 신청
박영기 / 2008 / 복분자 딸기 열매의 품종별 기능성 성분 및 항산화 활성 / 목재공학 36(1):102~109
치용카이 / 2013 / 식용 및 약용버섯의 항산화 및 In vitro 항암 효과 / 한국식품영양과학회지 42(5):655~662
Re R / 1999 / Antioxidant activity applying an improved ABTS radical cation decolorization assay / Free Radic Biol Med 26:1231~1237
Rhee SJ / 1984 / Change of lipid content and histochemical observation in liver of rats fed high fat diet / Korean J Nutr 17:113~125
송윤오 / 2013 / 고지방 식이에 의한 흰쥐의 지방간증에서 오미자 추출물의 간보호 효과 / 한국가축위생학회지 36(1):45~52
치용카이 / 2013 / 식용 및 약용버섯의 항산화 및 In vitro 항암 효과 / 한국식품영양과학회지 42(5):655~662
Re R / 1999 / Antioxidant activity applying an improved ABTS radical cation decolorization assay / Free Radic Biol Med 26:1231~1237
Rhee SJ / 1984 / Change of lipid content and histochemical observation in liver of rats fed high fat diet / Korean J Nutr 17:113~125
송윤오 / 2013 / 고지방 식이에 의한 흰쥐의 지방간증에서 오미자 추출물의 간보호 효과 / 한국가축위생학회지 36(1):45~52
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