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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.39 No.3
- 발행연도
- 2024.9
- 수록면
- 12 - 20 (9page)
이용수
초록· 키워드
오류제보하기
Previous research on the well-known environmental pollutant fluoride has demonstrated that fluoride exposure can lead to oxidative stress-related male infertility. Obesity is another public health issue that has a detrimental impact on male fertility. Previously, findings on fluoride toxicity in high-fat diet (HFD) conditions associated with oxidative stress have been evidenced. This study aimed to evaluate the impact of subchronic fluoride exposure (5 mg/kg) plus a HFD on testicular alteration in Wistar rats. Animals were divided into four groups (control, HFD, fluoride, and fluoride 5 mg/kg plus HFD). The HFD contained a 50% kcal increase in fat (saturated fat), after 90 days of co-exposure to fluoride plus HFD, the animals showed a significant decrease in the adiposity index. The co-exposed group showed oxidative damage assessed through decreased glutathione (GSH) concentration (p < 0.0001), increased concentrations of malondialdehyde (MDA) (p < 0.0001), and the oxidation of proteins (p < 0.0001) vs the control group. Finally, testicular histology exhibited a reduction in spermatogonia and spermatocytes. The results of the study indicate that under these conditions, subchronic co-exposure to fluoride under HFD conditions could protect against the accumulation of epididymal fat, however, oxidative alteration at the testicular level is maintained..
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (50)
참고문헌 신청
Wang Y, Li J, Ma T, Xie X, Deng Y, Gan Y. Genesis of geogenic contaminated groundwater: As, F and I. Critical Reviews in Environmental Science and Technology 2021;51(24):2895-2933. https://doi.org/10.1080/10643389.2020.1807452
Luo W, Gao X, Zhang X. Geochemical processes controlling the groundwater chemistry and fluoride contamination in the Yuncheng Basin, China—An area with complex hydrogeochemical conditions. PLoS One 2018;13(7):e0199082. https://doi.org/10.1371/journal.pone.0199082
Yousefi M, Asghari FB, Zuccarello P, Oliveri Conti G, Ejlali A, Mohammadi AA, et al. Spatial distribution variation and probabilistic risk assessment of exposure to fluoride in ground water supplies: A case study in an endemic fluorosis region of Northwest Iran. Int J Environ Res Public Health 2019;16(4):564. https://doi.org/10.3390/ijerph16040564
Husejnović MŠ, Turkić A, Halilčević A, Hadžić N, Mahmutbegović H. Deterministic and probabilistic human health risk assessment for fluorides in drinking groundwater from Lukavac, Bosnia and Herzegovina. Environ Anal Health Toxicol 2022;37(2):e2022016. https://doi.org/10.5620/eaht.2022016
Gupta AK, Ayoob S. Fluoride in drinking water: Status, issues, and solutions. CRC Press; 2016.
Luo W, Gao X, Zhang X. Geochemical processes controlling the groundwater chemistry and fluoride contamination in the Yuncheng Basin, China—An area with complex hydrogeochemical conditions. PLoS One 2018;13(7):e0199082. https://doi.org/10.1371/journal.pone.0199082
Yousefi M, Asghari FB, Zuccarello P, Oliveri Conti G, Ejlali A, Mohammadi AA, et al. Spatial distribution variation and probabilistic risk assessment of exposure to fluoride in ground water supplies: A case study in an endemic fluorosis region of Northwest Iran. Int J Environ Res Public Health 2019;16(4):564. https://doi.org/10.3390/ijerph16040564
Husejnović MŠ, Turkić A, Halilčević A, Hadžić N, Mahmutbegović H. Deterministic and probabilistic human health risk assessment for fluorides in drinking groundwater from Lukavac, Bosnia and Herzegovina. Environ Anal Health Toxicol 2022;37(2):e2022016. https://doi.org/10.5620/eaht.2022016
Gupta AK, Ayoob S. Fluoride in drinking water: Status, issues, and solutions. CRC Press; 2016.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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