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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 393 - 406 (14page)
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Bovine tuberculosis is an important zoonosis worldwide. Mycobacterium bovis, the causative agent of this disease in cattle, is also a pathogen for humans and several economically important animals. The cases of tuberculosis are reported in two cow found at slaughter house located in Gwangju city. Histopathologically, in the lymph nodes, granulomas consisted of large areas of necrosis surrounded by variable thick bands of cellular infiltrate containing macrophages, Langhanstype multinucleated giant cells and lymphocytes. Lesions in the lung followed the same developmental pattern as did lesions in the lymph nodes with some exceptions. With the acidfast staining, numerous mycobacteria were revealed in the lung and lymph nodes. M bovis was confirmed as a causative agent in these cattle using bacterial isolation and PCR and restriction fragment length polymorphism method based on a unique 12.7kb fragment insertion sequence from the Mycobacterium tuberculosis genome and the pncA polymorphism. The insertion element IS6110 and IS1081 were present M bovis isolated from lungs and lymph nodes of cattle using PCR assay. *Corresponding authorPhone : +82-62-571-0498, Fax : +82-62-571-0496E-mail: barada@hanmail.net These cases are interesting and important in public health aspect that M bovisinfected cattle were found during a routine postmortem inspection at slaughter house.
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참고문헌 (26)
참고문헌 신청
/ / McCracken RM. 1986. Pulmonary lesions and Mycobacterium bovis excretion from the respiratory tract of tuberculin reacting cattle. Vet Rec 118 : 718 ~ 21
/ / McDermott W. 1967. Pyrazinamide susceptibility and amidase acitivity of tubercle bacilli. Am Rev Respir Dis 95 : 461 ~ 469
/ / Stephens DM. 1991. Iden-tification of an insertion sequence : 11 ~ 15
/ / an IS-like element of Mycobacterium tuberculo-sis complex. Nucleic Acids Res 18 : 188 ~
/ / et al. 1991. Use of a reamplifi-cation protocol improves sensitivity of detection of Mycobacterium tuber-culosis in clinical samples. J Clin Microbiol 29 : 712 ~ 717
/ / McDermott W. 1967. Pyrazinamide susceptibility and amidase acitivity of tubercle bacilli. Am Rev Respir Dis 95 : 461 ~ 469
/ / Stephens DM. 1991. Iden-tification of an insertion sequence : 11 ~ 15
/ / an IS-like element of Mycobacterium tuberculo-sis complex. Nucleic Acids Res 18 : 188 ~
/ / et al. 1991. Use of a reamplifi-cation protocol improves sensitivity of detection of Mycobacterium tuber-culosis in clinical samples. J Clin Microbiol 29 : 712 ~ 717
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