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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 197 - 200 (4page)
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Bacillus Calmette-Guërin (BCG) has been traditionally used as a vaccine against tuberculosis. Further, intravesical administration of BCG has been shown to be effective in treating bladder cancer. Although BCG contains a live attenuated strain of Mycobacterium bovis, complications such as M. bovis BCG infection caused by BCG administration are extremely rare. Here, we report a case of BCG infection occurring after intravesical BCG therapy. A 67-yr-old man presented with azotemia and weight loss. He had been diagnosed with bladder cancer 4 yr back, and had undergone transurethral resection of the bladder tumor and intravesical BCG (Tice strain) therapy at that time. An acid-fast bacterial strain was isolated from his urine sample. We did not detect Mycobacterium tuberculosis protein 64 (MPT-64) antigen in the isolates obtained from his sample, and multiplex PCR and PCR-reverse blot hybridization assay indicated that the isolate was a member of the M. tuberculosis complex, but was not M. tuberculosis. Finally, sequence analysis of 16S ribosomal RNA and DNA gyrase, subunit B (gyrB) suggested that the organism was M. bovis or M. bovis BCG. Although we could not confirm that M. bovis BCG was the causative agent, the results of the 3 molecular methods and the MPT-64 antigen assay suggest this finding. This is an important finding, especially because M. bovis BCG cannot be identified using common commercial molecular genetics tools.
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참고문헌 (17)
참고문헌 신청
Behr MA / 1999 / A historical and molecular phylogeny of BCG strains / Vaccine 17 : 915 ~ 922
Bellmunt J / 2010 / Bladder cancer: ESMO practice guidelines for diagnosis, treatment and follow-up / Ann Oncol 21 (5) : 134 ~ 136
CLSI / 2008 / Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; approved guideline. CLSI document MM18-A / Clinical and Laboratory Standards Instit
Harboe M / 1986 / Properties of proteins MPB64, MPB70, and MPB80 of mycobacterium bovis BCG / Infect Immun 52 : 293 ~ 302
Harving SS / 2009 / Granulomatous epididymo-orchitis, a rare complication of intravesical bacillus Calmette-Guerin therapy for urothelial cancer / Scand J Urol Nephrol 43 : 3
Bellmunt J / 2010 / Bladder cancer: ESMO practice guidelines for diagnosis, treatment and follow-up / Ann Oncol 21 (5) : 134 ~ 136
CLSI / 2008 / Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; approved guideline. CLSI document MM18-A / Clinical and Laboratory Standards Instit
Harboe M / 1986 / Properties of proteins MPB64, MPB70, and MPB80 of mycobacterium bovis BCG / Infect Immun 52 : 293 ~ 302
Harving SS / 2009 / Granulomatous epididymo-orchitis, a rare complication of intravesical bacillus Calmette-Guerin therapy for urothelial cancer / Scand J Urol Nephrol 43 : 3
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