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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 285 - 293 (9page)
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초록· 키워드
오류제보하기
Globally, 1.3 million people develop colon cancer every year, and 600,000 people die each year it.
In Korea, colorectal carcinoma was associated with the highest death rate, accounting for 8,380 people, among solid cancers in 2015. Among the various methods for the diagnosis and study of colorectal carcinoma, the results obtained by cytogenetic and molecular genetic methods were compared. Detection rate was 47% in 18q, 40% in 17p , 27% in 22q, and 17% in 10q via CGH; detection rate was 57% in D18S59, 50% in D18S68, 50% in TP53CA, 47% in D18S6940% in D22S274, 37% in D22S283, 27% in D10S187, and 23% in D10S541 with LOH. Microsatellite marker matching rates were 100% in D22S274, 100% in D22S283, 100% in D10S186, 100% in D10S187, 100% in D10S541, 93% in D18S69, 93% in D18S68, 92% in TP53CA, and 89% in D18S59. The agreement rate between the two methods was 94.4% based on positive results using CGH. Based on the advantages of CGH, which was the ability to obtain information regarding the entire tumor genome at once, this experiment could identify the region with significant deletion using CGH and the more limited region LOH, with a completely different approach. LOH in the recurrent high-risk group, 18q21, was helpful in the selection of treatment modalities and in prognostic estimation as well as making the most appropriate decision for treatment. Therefore, it is suggested that LOH with surgical site tissues could be one of the treatment methods for recurrent high-risk group among patients with colorectal carcinoma.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Chih-Yung Yang / 2014 / Single Nucleotide Polymorphisms Associated with Colorectal Cancer Susceptibility and Loss of Heterozygosity in a Taiwanese Population / PLoS ONE 9 (6)
Datta A / 2016 / Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53 / Genom Dat
De Angelis PM / 1999 / Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
Grade M / 2006 / Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact / Cell Oncol 28 (3) : 71 ~ 84
Guo T / 2008 / Allelic imbalance on chromosomes 3p, 9p and 17p in malignant progression of laryngeal mucosa / J Laryngol Otol 122 (1) : 72 ~ 77
Datta A / 2016 / Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53 / Genom Dat
De Angelis PM / 1999 / Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
Grade M / 2006 / Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact / Cell Oncol 28 (3) : 71 ~ 84
Guo T / 2008 / Allelic imbalance on chromosomes 3p, 9p and 17p in malignant progression of laryngeal mucosa / J Laryngol Otol 122 (1) : 72 ~ 77
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