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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제2권 제4호
- 발행연도
- 2009.1
- 수록면
- 175 - 180 (6page)
이용수
초록· 키워드
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Objectives. Respiratory epithelial cells are the first site of interaction of allergens with the immune system. The aim of
this study was to examine the effect of epithelial cells, which were stimulated with house dust mite (HDM) extracts,
on the immune response of peripheral blood mononuclear cells (PBMCs).
Methods. Primary nasal polyp epithelial cells were exposed to dermatophagoides pteronyssinus and dermatophagoides
farina for 48 hr, and then the supernatant and cells were collected. After stimulation with HDM extract, the epithelial
cells were co-cultured with PBMCs for 72 hr and then the supernatant was collected. We measured the interleukin
(IL)-8 and granulocyte-macrophage colony stimulating factor to determine the activation of the epithelial
cells. The tumor necrosis factor (TNF)-a, IL-5 and interferon-g were measured to evaluate the interaction between
the epithelial cells and the PBMCs. The mRNA expression of intercellular adhesion molecule 1 (ICAM-1) was
assessed using the anti-ICAM-1 antibody.
Results. The HDM extracts activated the nasal epithelial cells and enhanced the expression of ICAM-1 mRNA and cell
membrane ICAM-1. When the activated epithelial cells were co-cultured with PBMCs, the PBMCs produced lager
amounts of TNF-a and IL-5. However the cytokine production was not inhibited by pretreatment with ICAM-1
antibody.
Conclusion. HDM allergens induce allergic inflammation by activating nasal epithelial cells, yet the interaction of the
epitheila cells and the PBMCs may not be associated with an ICAM-1 medicated mechanism.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Agace WW / 2000 / Tlymphocyte-epithelial-cell interaction: integrin aE(CD103)b7, LEEPCAM and chemokines / Curr Opin Cell Biol 12 (5) : 563 ~ 568
Asokananthan N / 2002 / House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: The cytokine protease allergen, Der p 1, activated prot
De Wit D / 2000 / Helper T-cell responses elicited by Der p1-pulsed dendritic cells and recombinant IL-12 in atopic and healthy subjects / J Allergy Clin Immunol 105 (2) : 3
Herbert CA / 1995 / Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1 / Am J Respir Cell Mol Biol 12 (4) : 369 ~ 378
Kimura M / 1998 / Correlation of house dust mite-specific lymphocyte proliferation with IL-5 production, eosinophilila, and the severity of symptoms in infants with atopic d
Asokananthan N / 2002 / House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: The cytokine protease allergen, Der p 1, activated prot
De Wit D / 2000 / Helper T-cell responses elicited by Der p1-pulsed dendritic cells and recombinant IL-12 in atopic and healthy subjects / J Allergy Clin Immunol 105 (2) : 3
Herbert CA / 1995 / Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1 / Am J Respir Cell Mol Biol 12 (4) : 369 ~ 378
Kimura M / 1998 / Correlation of house dust mite-specific lymphocyte proliferation with IL-5 production, eosinophilila, and the severity of symptoms in infants with atopic d
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