지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.12
- 수록면
- 441 - 446 (6page)
이용수
초록· 키워드
오류제보하기
The molecular mechanism of ischemia / reperfusion injury remains unclear, Reactive oxygen species (ROS) are implicated in cell death caused by ischemia/reperfusion in vivo or hypoxia in vitro. Poly (ADP-ribose) polymerase (PARP) activation has been reported to be involved in hydrogen peroxide-induced cell death in renal epithelial cells. This study was therefore undertaken to evaluate the role of PARP activation in chemical hypoxia in opossum kidney (OK) cells. Chemical hypoxia was induced by incubating cells with antimycin A, an inhibitor of mitochondrial electron transport. Exposure of OK cells to chemical hypoxia resulted in a time-dependent cell death. In OK cells subjected to chemical hypoxia, the generation of ROS was increased, and this increase was prevented by the H<sub>2</sub>O<sub>2</sub> scavenger catalase. Chemical hypoxia increased PARP activity and chemical hypoxia-induced cell death was prevented by the inhibitor of PARP activation 3-aminobenzamide. Catalase prevented OK cell death induced by chemical hypoxia. H<sub>2</sub>O<sub>2</sub> caused PARP activation and H<sub>2</sub>O<sub>2</sub>-induced cell death was prevented by 3-aminobenzamide. Taken together, these results indicate that chemical hypoxia-induced cell injury is mediated by PARP activation through H<sub>2</sub>O<sub>2</sub> generation in renal epithelial cells.
목차
영어초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Role of Lipid Peroxidation on H₂O₂-Induced Renal Cell Death in Cultured Cells and Freshly Isolated Cells
대한의생명과학회지
2002 .12
-
진균에 의해 활성화된 호흡상피세포와 말초혈액 면역세포의 상호작용
대한이비인후-두경부외과학회지
2008 .01
-
HeLa와 Saccharomyces cerevisiae에서 세포주기와는 관련 되나 MMS 상해 와는 무관한 Poly ( ADP-Ribose ) Polymerase 유전자의 발현 ( Expression of Poly ( ADP-Ribose ) Polymerase Gene is Related to Cell Cycle Progression but not to MMS Damage in HeLa and Saccharomyces cerevisiae cells )
한국환경성돌연변이·발암원학회지
1994 .03
-
Cell Cycle Regulatory Protein Expression Profiles by Adenovirus p53 Infection in Human Papilloma Virus-associated Cervical Cancer Cells
Cancer Research and Treatment
2006 .01
-
Effect of Baicalein on t-Butylhydroperoxide-Induced Cell Injury in Renal Tubular Epithelial Cells
대한의생명과학회지
2003 .12
-
effect of 6 ( 5h ) -phenanthridinone , a poly ( ADP-ribose ) polymerase inhibitor , and ionizing radiation on the growth of cultured lymphoma cells
한국독성학회보
1998 .06
-
Th2 Responses Elicited by Nasal Epithelial Cells Exposed to House Dust Mite Extract
Clinical and Experimental Otorhinolaryngology
2009 .01
-
The Prognostic Implications of Cystic Change in Clear Cell Renal Cell Carcinoma
Journal of Pathology and Translational Medicine
2010 .01
-
NF-κB Inhibitor Suppresses Hypoxia-induced Apoptosis of Mouse Pancreatic β-cell Line MIN6
대한의생명과학회지
2014 .03
-
Protective Effects of Verapamil against H<sub>2</sub>O<sub>2</sub>-Induced Apoptosis in Human Lens Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Renal Actinomycosis Initially Misdiagnosed as Renal Cell Carcinoma with Renal Vein Thrombosis
Urogenital Tract Infection
2016 .01
-
Effects of Human Adipose-Derived Stem Cells in Regenerating the Damaged Renal Tubular Epithelial Cells in an Animal Model of Cisplatin-Induced Acute Kidney Injury
Childhood Kidney Diseases
2015 .01
-
Beneficial Effect of Pentoxifylline on Hypoxia-Induced Cell Injury in Renal Proximal Tubular Cells
대한의생명과학회지
2004 .12
-
Ipsilateral Synchronous Renal Cell Carcinoma and Transitional Cell Carcinoma- A Case Report -
Journal of Pathology and Translational Medicine
2002 .01
-
나선식 CT를 이용한 혐색소형 신세포암과 투명세포형 신세포암의 감별
영남의대학술지
2012 .01
-
Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Immune Network
2006 .03
-
Lung epithelial cell injury is associated with bleomycininduced cell cycle arrest via upregulation of p21Cip1
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Cell cycle arrest of alveolar epithelial cells is critical in the pathogenesis of idiopathic pulmonary fibrosis
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-017356821