흰쥐 유양동 폐쇄술에 사용한 Hydroxyapatite Cement와 Demineralized Bone Matrix의 효과 및 조직병리학적 비교 연구

구태우; 장윤석; 김소향; 김수진; 홍숙희; 강명구

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자료유형: 학술저널

저자정보: 구태우 장윤석 김소향 김수진 홍숙희 강명구

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제9호

발행연도: 2008.1

수록면: 777 - 782 (6page)

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Mastoid obliteration surgery is a useful technique for otitis media either with or without cholesteatoma. Obliterating materials have to satisfy low antigenecity, less inflammation, little tissue resorption, high regeneration power and good integration into the host tissue. The aim of our study is to evaluate histopathological changes and effectiveness resulting from the different obliterating materials in the temporal dorsal bullae in rats. Materials and Method：We divided the rats into two groups. Group A was untreated, but group B underwent removal of mastoid mucosa with 2% trichloroacetic acid (TCA). Both groups had mastoid obliteration by the implantation of hydroxyapatite cement (Mimix®) and demineralized bone matrix (Regenafil®). Twelve weeks after the implantation, a histological study was performed to evaluate remaining implanted material, new bone formation and the formation of cysts within the bullae. Results：There was no or minimal inflammation or foreign body reactions in the mastoid obliteration groups with Mimix® and Regenafil®. In the obliterated group that was not treated with 2% TCA, the remaining implanted material with Mimix® group was more than in the Regenafil® group (p<0.05). The obliterated groups of Mimix® and Regenafil® were similar with respect to new bone formation. The mucocele formation in the obliterated groups treated with 2% TCA was less than in the obliterated groups not treated with 2% TCA (p<0.05). Conclusion：We suggest that Mimix® and Regenafil® could be valuable resources as graft materials for mastoid obliteration procedures. The research continues for evaluation of long term results of these materials and their potential as graft materials. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:777-82)

#Hydroxyapatite cement·Bone matrix·Rats.

참고문헌 (17)

참고문헌 신청

Dornhoffer J / 2003 / Canal wall reconstruction with mimix hydroxyapatite cement: Results in an animal model and case study / Laryngoscope 113 (12) : 2123 ~ 2128

Edwards JT / 1998 / Osteoinduction of human demineralized bone: Characterization in a rat model / Clin Orthop Relat Res 1 (357) : 219 ~ 228

Estrem SA / 1999 / Hydroxyapatite canal wall reconstruction/ mastoid obliteration / Otolaryngol Head and Neck Surg 120 (3) : 345 ~ 349

Groenveld EH / 1999 / Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations / J Biomed Materials Res 48 (4) : 393 ~ 402

Hartwein, Hormann K / 1990 / A technique for the reconstruction of the posterior canal wall and mastoid obliteration in radical cavity surgery / Am J Otol 11 (3) : 169 ~ 173

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