흰쥐 유양동 폐쇄술 후 시간에 따른 조직학적 변화

박정홍; 구태우; 박병건; 장윤석; 강명구

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자료유형: 학술저널

저자정보: 박정홍 구태우 박병건 장윤석 강명구

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제3호

발행연도: 2009.1

수록면: 220 - 227 (8page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background and Objectives：Mastoid obliteration surgery is a modern trend for otitis media either with or without cholesteatoma. The aim of our study is to evaluate histologic changes and effectiveness over time resulting from different obliterating materials and the existence of mucosa in the temporal dorsal bullae in rats. Materials and Method：Rats were divided into two groups. One group had the mucosa removed and was treated with trichloroacetic acid (TCA). The other group with mucosa remaining was untreated. The temporal dorsal bullae of the two groups of rats were obliterated with Mimix® (hydroxyapatite cement), Regenafil® (demineralized bone matrix), cartilage chip, and bone chip. Three months and again six months after the implantation, 5 animals in each group were examined. A histological study was performed to evaluate inflammation, new bone formation, and mucocele formation within the bullae. Results：The group that had Mimix® implanted had a high inflammatory reaction, low implanted material resorption and cyst formation. The group with Regenafil® implanted had high cyst formation and more cyst formation with the passage of time. The group with bone chip implanted had high new bone formation, but also high cyst formation. The group that had cartilage chip implanted had high new bone formation, low implanted material resorption and low cyst formation. Conclusion：Cartilage chip is the only material that should be used in the air cell with mucosa remaining. Demineralized bone matrix and bone chip should not be used in the air cell with mucosa remaining. Hydroxyapatite cement should not be used due to severe inflammation.

#폐쇄술·수산화 인회석 시멘트·탈무기질화 골 기질·골·연골 #Obliteration·Hydroxyapatite cement·Demineralized bone matrix·Bone·Cartilage

참고문헌 (19)

참고문헌 신청

Beales PH / 1969 / Complications following obliterative mastoid operation / Arch Otolaryngol 89 (1) : 196 ~ 198

Dornhoffer J / 2003 / Canal wall reconstruction with Mimix hydroxyapatite cement: Results in an animal model and case study / Laryngoscope 113 (12) : 2123 ~ 2128

Dornhoffer JL / 2008 / Impact on quality of life after mastoid obliteration / Laryngoscope 118 (8) : 1427 ~ 1432

Edwards JT / 1998 / Osteoinduction of human demineralized bone: Characterization in a rat model / Clin Orthop Relat Res (357) : 219 ~ 228

Jang CH / 2002 / Changes in external ear resonance after mastoidectomy: Open cavity mastoid versus obliterated mastoid cavity / Clin Otolaryngol Allied Sci 27 (6) : 509 ~ 511

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