Hydroxyapatite를 이용한 흰 쥐 유양동 폐쇄술: 다양한 입자 크기의 Hydroxyapatite를  이용한 조직 병리학적 연구

김소향; 박정홍; 김수진; 강민영; 강명구

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자료유형: 학술저널

저자정보: 김소향 박정홍 김수진 강민영 강명구

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제53권 제4호

발행연도: 2010.1

수록면: 209 - 214 (6page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background and ObjectivesZZMastoid obliteration is the technique developed to reduce cavity problems after canal wall down mastoidectomy. Different materials have been explored for the technique, and of the variety of materials that have been used for mastoid obliteration, hydroxyapatite has gained particular attention. Hydroxyapatite can be made into a specific particle size, which affects the postoperative result. The aim of this study is to evaluate the histopathologic findings of mastoids obliterated with various particle sizes of hydroxyapatite in the temporal bullae of rat. Materials and MethodZZRat bullaes were obliterated with hydroxyapatite and diversified into different particle sizes. In group 1, the mastoids were obliterated with Mimix® powder and in groups 2, 3, 4 with Bongros®. The particle sizes were 0.3-0.6 mm, 0.6-1.0 mm and 1.0-3.0mm each. After 3 months, the mastoids were examined under the microscope. ResultsZZIn group 1, a new bone was formed in a consecutive fashion from the mastoid wall toward the center of the mastoid; there was no inflammation, with the new bone formation constituting 15%. In group 2, 3, 4, the proportion of new bone formation was higher than in the group 1, and constituted 40%, 55% and 60%, respectively. Inflammation was more severe when the particle size became larger. ConclusionZZNew bone formation was faster if larger hydroxyapatite particles were used;however, inflammation also increased. The powder form of hydroxyapatite was slow in new bone formation, but there was little inflammation. We therefore think that the hydroxyapatite is a very safe material. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:209-14

#Temporal bone·Mastoid·Osteogenesis·Hydroxyapatites·Particle size.

참고문헌 (22)

참고문헌 신청

Andrade JC / 2002 / Behavior of dense and porous hydroxyapatite implants and tissue response in rat femoral defects / J Biomed Mater Res 62 (1) : 30 ~ 36

Athanasiou VT / 2010 / Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits / Me

Ayers RA / 1999 / Quantification of bone ingrowth into porous block hydroxyapatite in humans / J Biomed Mater Res 47 (1) : 54 ~ 59

Barrere F / 2006 / Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics / Int J Nanomedicine 1 (3) : 317 ~ 332

Carvalho AL / 2007 / Taba MJ, Palioto DB, et al. Effects of granule size on the osteoconductivity of bovine and synthetic hydroxyapatite: a histologic and histometric study i

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