지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 1,289 - 1,296 (8page)
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Background and Objectives：Dendritic cells (DC) can effectively mediate the prevention and regression of a variety of solid
malignancies when they are properly primed with tumor antigens. However, little has been determined about the efficacy of DCbased
vaccine for the prevention of squamous cell carcinoma (SCC). Subjects and Method：Bone marrow derived DC of
C3H mouse were pulsed with ultraviolet B-irradiated apoptotic SCCVII cells, which are known as a poorly immunogenic SCC
cell line. After vaccinations with those DC, a tumorigenic dosage of healthy SCCVII cells were challenged into the flank of animals
and the tumor growth was assessed in a blinded and coded fashion. Results：DC pulsed with apoptotic SCCVII cells effectively
prevented the formation of solid tumor in 81% of vaccinated animals and mediated significant retardation of tumor growth
(p=0.0029) in 19% of vaccinated animals when compared to control groups. SCCVII cell-specific T-cell response (IFN-γ
production) was observed in the immunized mice. Conclusion：Adoptive transfer of DC primed with apoptotic SCCVII cells
can serve as an effective preventive vaccine in the poorly immunogenic SCC animal model.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
/ 1970 / The concept of immunological surveillance
/ 1973 / Identification of a novel cell type in peripherallymphoid organs of mice. I. Morphology, quantitation, tissue distribution. 137 : 1142 ~ 1162
/ 1990 / The absence of lymphoid suppressor cells in tumor-involved lymph nodesof patients with head and neck cancer 130 : 446 ~ 458
/ 1992 / Generation of large numbers of dendritic cells from mouse bone marrowcultures supplemented with granulocyte/macrophage colony-stimulatingfactor 176 : 1693 ~ 1702
/ 1993 / Quantificationof apoptosis and necrosis by flow cytometry 32 : 417 ~ 424
/ 1973 / Identification of a novel cell type in peripherallymphoid organs of mice. I. Morphology, quantitation, tissue distribution. 137 : 1142 ~ 1162
/ 1990 / The absence of lymphoid suppressor cells in tumor-involved lymph nodesof patients with head and neck cancer 130 : 446 ~ 458
/ 1992 / Generation of large numbers of dendritic cells from mouse bone marrowcultures supplemented with granulocyte/macrophage colony-stimulatingfactor 176 : 1693 ~ 1702
/ 1993 / Quantificationof apoptosis and necrosis by flow cytometry 32 : 417 ~ 424
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