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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 206 - 211 (6page)
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초록· 키워드
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Dendritic cell (DC)-based tumor vaccine is an attractive modality for the treatment of colon cancer because it has been recurred and produced few side effects in patients. Secretory glycoprotein 90K has been found at elevated level in various cancer tissues and sera. We investigated to establish a more effective DC vaccine for the treatment of colon cancer in which the levels of 90K are elevated. Methods: We obtained the concentrated 90K from 293T cells stably expressing 90K. DCs were cultured from peripheral blood monocytes, and a DC vaccine pulsed with tumor lysate was compared with a DC vaccine pulsed with 90K. We measured the functional activity for CTLs by using IFN-γ-enzyme linked immunoabsorbent spot (ELISPOT) assay. Results: DCs pulsed with tumor lysate+90K exhibited the enhanced T cell stimulation, polarization of i T cell toward Th1. The CTLs generated by DCs pulsed with 90K efficiently lysed HCT116 cells. The results indicate that 90K-speicifc-CTLs can recognize 90K proteins naturally presented by colon cancer cells. Conclusion: Our study suggests that 90K-specific CTLs generated by 90K-pulsed DCs could be useful effector cells for immunotherapy in colon cancer.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Banchereau J / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
2. [학술지(정기간행물)] - Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
3. [학술지(정기간행물)] - Steinman RM / 2001 / Active immunization against cancer with dendritic cells: the near future / Int J Cancer 94 : 459 ~ 473
4. [학술지(정기간행물)] - Zitvogel L / 1996 / Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines / J Exp Med 183 : 87 ~ 97
5. [학술지(정기간행물)] - Kaplan JM / 1999 / Induction of antitumor immunity with dendritic cells transduced with adenovirus vector-encoding endogenous tumor-associated antigens / J Immunol 163 : 699 ~ 707
2. [학술지(정기간행물)] - Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
3. [학술지(정기간행물)] - Steinman RM / 2001 / Active immunization against cancer with dendritic cells: the near future / Int J Cancer 94 : 459 ~ 473
4. [학술지(정기간행물)] - Zitvogel L / 1996 / Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines / J Exp Med 183 : 87 ~ 97
5. [학술지(정기간행물)] - Kaplan JM / 1999 / Induction of antitumor immunity with dendritic cells transduced with adenovirus vector-encoding endogenous tumor-associated antigens / J Immunol 163 : 699 ~ 707
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