Anti-tumor Efficacy of a Hepatocellular Carcinoma Vaccine Based on Dendritic Cells Combined with Tumor-derived Autophagosomes in Murine Models

Su, Shu; Zhou, Hao; Xue, Meng; Liu, Jing-Yu; Ding, Lei; Cao, Meng; Zhou, Zhen-Xian; Hu, Hong-Min; Wang, Li-Xin

추천

검색

자료유형: 학술저널

저자정보: Su, Shu (Cancer Research and Biotherapy Center, the Affiliated Nanjing Second Hospital, Medical School of Southeast University) Zhou, Hao (Department of Microbiology and Immunology, Medical School of Southeast University) Xue, Meng (Department of Microbiology and Immunology, Medical School of Southeast University) Liu, Jing-Yu (Department of Microbiology and Immunology, Medical School of Southeast University) Ding, Lei (Department of Microbiology and Immunology, Medical School of Southeast University) Cao, Meng (Department of Microbiology and Immunology, Medical School of Southeast University) Zhou, Zhen-Xian (Cancer Research and Biotherapy Center, the Affiliated Nanjing Second Hospital, Medical School of Southeast University) Hu, Hong-Min (Cancer Research and Biotherapy Center, the Affiliated Nanjing Second Hospital, Medical School of Southeast University) Wang, Li-Xin (Cancer Research and Biotherapy Center, the Affiliated Nanjing Second Hospital, Medical School of Southeast University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제5호

발행연도: 2013.1

수록면: 3,109 - 3,116 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

The majority of hepatocellular carcinoma (HCC) patients have a poor prognosis with current therapies, and new approaches are urgently needed. We have developed a novel therapeutic cancer vaccine platform based on tumor cell derived autophagosomes (DRibbles) for cancer immunotherapy. We here evaluated the effectiveness of DRibbles-pulsed dendritic cell (DC) immunization to induce anti-tumor immunity in BALB/c mouse HCC and humanized HCC mouse models generated by transplantation of human HCC cells (HepG2) into BALB/c-nu mice. DRibbles were enriched from H22 or BNL cells, BALB/c-derived HCC cell lines, by inducing autophagy and blocking protein degradation. DRibbles-pulsed DC immunization induced a specific T cell response against HCC and resulted in significant inhibition of tumor growth compared to mice treated with DCs alone. Antitumor efficacy of the DCs-DRibbles vaccine was also demonstrated in a humanized HCC mouse model. The results indicated that HCC/DRibbles-pulsed DCs immunotherapy might be useful for suppressing the growth of residual tumors after primary therapy of human HCC.

#Hepatocellular carcinoma #dendritic cells #autophagy #immunotherapy #tumor antigen #cross-presentation

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Su, Shu

소속기관 Cancer Research and Biotherapy Center, the Affiliated Nanjing Second Hospital, Medical School of Sou