갑상선 유두상 암종에서의 COX-2와 VEGF-C의 발현과 예후인자들과의 관계

우정수; 김광일; 백승국; 정광윤; 권순영

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자료유형: 학술저널

저자정보: 우정수 김광일 백승국 정광윤 권순영

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제12호

발행연도: 2004.1

수록면: 1,273 - 1,277 (5page)

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Background and Objectives：Cycloxygenase-2 (COX-2) may play a role in tumor growth and spread of numerous types of epithelial cancers since it can regulate tumor angiogenesis by modulating the production of several angiogenic factors, including vascular endothelial growth factor (VEGF). We investigated the corelation between COX-2 and VEGF-C expresions and diferent prognostic factors of thyroid papillary carcinoma. Subjects and Method：Thirty-eight patients with thyroid papillary semiquantitative scoring method was employed to determine their expression levels. The imunostaining scores were compared with diferent prognostic factors of thyroid papillary carcinoma. Results：The mean scores± SD for COX-2 and VEGF-C were 3.9± 3.6 and 4.7± 3.1, respectively, and there was a significant corelation between their expressions. Among the prognostic factors of thyroid papilary carcinoma, age, sex, and tumor size made no significant diferences betwen COX-2 and VEGF-C with nodal metastasis and extracapular spread. Conclusion：Nodal metastasis, tumor stage, and extracapsular spread were found to be associated with the expressions of COX-2 and VEGF-C, and were concerned with the growth and metastasis of tumor. Therefore, COX-2 and VEGF-C may play important roles in the tumor growth and metastasis of thyroid papilary carcinoma, as in other epithelial cancers.

#사이클로옥시게나제·제 C 형 혈과내피성장인자·갑상선암. #Cyclooxygenase·Vascular endothelial growth factor·Thyroid cancer.

참고문헌 (14)

참고문헌 신청

/ 1994 / Up-regulation of cyclooxygenase 2 gene expression inhuman colorectal adenomas and adenocarcinomas 107 : 1183 ~ 1188

/ 1996 / Transcription of cyclooxygenase-2 is enhanced intransformed mammary epithelial cells 56 : 4424 ~ 4429

/ 1998 / Increased expression of cyclooxygenase-2 occurs frequently inhuman lung cancers, specifically in adenocarcinomas. 58 : 3761 ~ 3764

/ 1999 / Cyclooxygenase-2 expression is up-regulated in squamous cell carcinomaof the head and neck 59 : 991 ~ 994

/ 1999 / Expression of angiogenesis stimulators and inhibitors in humanthyroid tumors and correlation with clinical pathological features 155 : 1967 ~ 1976

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