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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제1호
- 발행연도
- 2012.1
- 수록면
- 55 - 60 (6page)
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초록· 키워드
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Background: Overexpression of survivin, a member of the inhibitors of apoptosis protein, has been reported in various carcinomas, and its interaction with cyclooxygenase 2 (COX-2) results in accelerated tumor progression. The purpose of this study is to investigate the immunohistochemical expression of survivin and COX-2 in benign and malignant thyroid tissues and to define its association with pathologic and clinical features. Methods: We examined expression of survivin and COX-2 by immunohistochemistry in 334 benign and malignant thyroid tissues and evaluated their clinical significance. Results: Expression of survivin showed an increase along the spectrum of thyroid carcinoma progression; rarely positive in adenomatous goiter, moderately positive in papillary carcinoma, and strongly positive in anaplastic carcinoma (AC). Papillary microcarcinoma revealed the highest COX-2 positivity and AC demonstrated the lowest positivity among thyroid cancers. Node negative carcinomas showed higher COX-2 expression than node positive tumors. Survivin expression did not correlate with COX-2. Conclusions: Our findings suggest that survivin overexpression may be related to the pathogenesis of AC and can be a predictor of disease progression. COX-2 may be involved in the early phase of thyroid carcinoma.
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참고문헌 (25)
참고문헌 신청
Adida C / 2000 / Prognostic significance of survivin expression in diffuse large B-cell lymphomas / Blood 96 : 1921 ~ 1925
Ambrosini G / 1997 / A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma / Nat Med 3 : 917 ~ 921
Ambrosini G / 1998 / Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting / J Biol Chem 273 : 11177 ~ 11182
Antonaci A / 2008 / Survivin and cyclin D1 are jointly expressed in thyroid papillary carcinoma and microcarcinoma / Oncol Rep 20 : 63 ~ 67
Barnes N / 2006 / Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence / Br J Cancer 94 : 253 ~ 258
Ambrosini G / 1997 / A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma / Nat Med 3 : 917 ~ 921
Ambrosini G / 1998 / Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting / J Biol Chem 273 : 11177 ~ 11182
Antonaci A / 2008 / Survivin and cyclin D1 are jointly expressed in thyroid papillary carcinoma and microcarcinoma / Oncol Rep 20 : 63 ~ 67
Barnes N / 2006 / Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence / Br J Cancer 94 : 253 ~ 258
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