후각 소실된 마우스에서 국소용 스테로이드의 비강 내 주입이 후각 세포의 회복에 미치는 효과

박소영; 정대건; 조진희; 이동목; 김명원; 김병국

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자료유형: 학술저널

저자정보: 박소영 정대건 조진희 이동목 김명원 김병국

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제12호

발행연도: 2004.1

수록면: 1,256 - 1,260 (5page)

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연구결과

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Background and Objectives：The purpose of this study was to evaluate the efect of intranasal Mometasone furoate instillation into the nasal cavity of mice which had peripherally induced anosmia. Subjects and Method：Three groups of mice were stu-died：normal control group (nasal instillation of normal saline, n= 6), Mometasone furoate non-instillation group (no treatment after nasal instillation of zinc sulfate, n= 12), and Mometasone furoate instillation group (daily mometasone furoate instillation = 12). Tisues of olfactory mucosa were obtained on 1, 2, 3, 4 weeks after the instillation of zinc sulfate, and procesed for imunohistochemistry using antisera to olfactory marker protein (OMP) for evaluation of olfactory regeneration. Results：No OMP-positive cells were observed in the first wek after the instillation of zinc sulfate in both groups. However, OMP-positive cells began apearing in the secby. In the Mometasone furoate instillation group, the increase of OMP-positive cells was significantly greater than that of Mo-metasone furoate non-instillation group. Conclusion：Mometasone furoate instillation enhances regeneration of olfactory recep-tor cells after injury. Mometasone furoate instillation can be sugested as an efective treatment modality for olfactory dysfunction.

#무취증·후각·Zinc sulfate·후각 수용체 신경세포. #Anosmia· Olfaction· Zinc sulfate· Olfactory receptor neuron.

참고문헌 (15)

참고문헌 신청

/ 1978 / Denervation of the primaryolfactory pathway in mice. V. Long-term effect of intranasal ZnSO4irrigation on behavior, biochemistry and morphology 140 : 271 ~ 285

/ 1979 / A review of olfactory dysfunction in man 1 : 57 ~ 79

/ 1979 / Neurogenesis and neuron regenerationin the olfactory system of mammals I.Morphological aspect of differentiationand structural organization of the olfactory sensory

/ 1986 / The initial evaluation of dysosmia 4 : 431 ~ 444

/ 1987 / Zinc-induced peripheral anosmia andbehavioral responses to novelty in mice:A quantitative-genetic analysis 48 : 63 ~ 82

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