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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 265 - 274 (10page)
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초록· 키워드
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Inner ear is an important organ that is responsible for balance and hearing. It is composed of two complicated major subunits, vestibular organ and cochlea. During development, both functional units require complex genetic interactions to achieve proper patterning and morphology as its purpose. This review comprises three parts. In the first part, general information about technical tools in studying mouse ear development is introduced. In the second part, it is shown how semicircular canals are formed and what genetic interaction is involved in canal formation. In the last part, genetic interactions required for proper development of cochlea are elaborated, focusing on the length of cochlea and morphology of organ of Corti. The study about development of mutant mice provides us useful information about genetic interaction involved in the formation of structures for hearing and balance. The data acquired in the development field could provide a breakthrough to hair cell regeneration and stem cell therapy fields in stuck, which are directly applicable to human. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:265-74
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Balemans W / 2002 / Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators / Dev Biol 250 (2) : 231 ~ 250
Chen P / 1999 / p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti / Development 126 (8) : 1581 ~ 1590
Doetzlhofer A / 2009 / Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti / Dev Cell 16 (1) : 58 ~ 69
Driver EC / 2008 / Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans / J Neurosci 28 (29) : 7350 ~ 7358
Fekete DM / 1997 / Involvement of programmed cell death in morphogenesis of the vertebrate inner ear / Development 124 (12) : 2451 ~ 2461
Chen P / 1999 / p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti / Development 126 (8) : 1581 ~ 1590
Doetzlhofer A / 2009 / Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti / Dev Cell 16 (1) : 58 ~ 69
Driver EC / 2008 / Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans / J Neurosci 28 (29) : 7350 ~ 7358
Fekete DM / 1997 / Involvement of programmed cell death in morphogenesis of the vertebrate inner ear / Development 124 (12) : 2451 ~ 2461
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