지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 247 - 256 (10page)
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초록· 키워드
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Hearing loss is the most frequent sensory deficit in the human population and can occur at any age. Hearing loss ranges from mild to profound, can be conductive, sensorineural or mixed type and may be congenital or acquired. Sometimes, some of hearing loss can be cured by medical or surgical interventions but most of hearing loss is irreversible and many patients struggle in their daily activities and their quality of life suffers. Although hearing aids as well as cochlear implants can give good solution to patients with a hearing loss that cannot be cured, both of them have some limitations and cannot solve the hearing problem perfectly. Recent scientific achievements in cochlear stem cell research and regenerative medicine can suggest ultimate solution to researchers as well as doctors and can give a hope to patients with a hearing loss and their family. Until now, mammalian cochlear hair cells have been known to be never replaced or regenerated, such that insults to the cochlea cause progressive and permanent hearing loss of variable degree. However, non-mammalian vertebrates are capable of replacing lost hair cells and have stem cells in their cochlea, which has recently led to efforts to understand the molecular and cellular basis of regenerative responses in different vertebrate species. In this article, I review the development of mammalian cochlea, focusing on the molecular events related with the development and regeneration. I also introduce the progress in overcoming the limits to mammalian cochlear hair cell regeneration and recent efforts to cochlear regenerative medicine.
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참고문헌 (68)
참고문헌 신청
Corwin JT / 1991 / Hair cell regeneration: the identities of progenitor cells, potential triggers and instructive cues / Ciba Found Symp 160:103~120
Stone JS / 2007 / Hair cell regeneration in the avian auditory epithelium / Int J Dev Biol 51(6):633~647
Roberson DW / 1996 / Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory epithelium / Aud Neurosci 2:11
Vater M / 2004 / Hearing organ evolution and specialization: early and later mammals / Springer-Verlag :256
Warchol ME / 1993 / Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans / Science 259(5101):1619~1622
Stone JS / 2007 / Hair cell regeneration in the avian auditory epithelium / Int J Dev Biol 51(6):633~647
Roberson DW / 1996 / Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory epithelium / Aud Neurosci 2:11
Vater M / 2004 / Hearing organ evolution and specialization: early and later mammals / Springer-Verlag :256
Warchol ME / 1993 / Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans / Science 259(5101):1619~1622
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