Comparison of Cochlear Morphology and Apoptosis in Mouse Models of Presbycusis

박시내; 박상아; 박경호; 김동기; 박소영; 오정훈; 박용수; 여상원

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자료유형: 학술저널

저자정보: 박시내 박상아 박경호 김동기 박소영 오정훈 박용수 여상원

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제3권 제3호

발행연도: 2010.1

수록면: 126 - 135 (10page)

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Objectives. Morphological studies on presbycusis, or age-related hearing loss, have been performed in several different strains of mice that demonstrate hearing loss with auditory pathology. The C57BL/6 (C57) mouse is a known model of early onset presbycusis, while the CBA mouse is characterized by relatively late onset hearing loss. We performed this study to further understand how early onset hearing loss is related with the aging process of the cochlea. Methods. We compared C57 cochlear pathology and its accompanying apoptotic processes to those in CBA mice. Hearing thresholds and outer hair cell functions have been evaluated by auditory brainstem response (ABR) recordings and distortion product otoacoustic emission (DPOAE). Results. ABR recordings and DPOAE studies demonstrated high frequency hearing loss in C57 mice at P3mo of age. Cochlear morphologic studies of P1mo C57 and CBA mice did not show differences in the organ of Corti, spiral ganglion, or stria vascularis. However, from P3mo and onwards, a predominant early outer hair cell degeneration at the basal turn of the cochlea in C57 mice without definitive degeneration of spiral ganglion cells and stria vascularis/spiral ligament, compared with CBA mice, was observed. Additionally, apoptotic processes in the C57 mice also demonstrated an earlier progression. Conclusion. These data suggest that the C57 mouse could be an excellent animal model for early onset ‘sensory’ presbycusis in their young age until P6mo. Further studies to investigate the intrinsic or extrinsic etiologic factors that lead to the early degeneration of organ of Corti, especially in the high frequency region, in C57 mice may provide a possible pathological mechanism of early onset hearing loss.

#Cochlea #Morphology #Hearing #Aging #Apoptosis.

참고문헌 (21)

참고문헌 신청

Anderson SD / 1979 / The evoked cochlear mechanical response in laboratory primates: a preliminary report / Arch Otorhinolaryngol 224 (1-2) : 47 ~ 54

Bronson RT / 1990 / Rate of occurrence of lesions in 20 inbred and hybrid genotypes of rats and mice sacrificed at 6 month intervals during the first years of life. In: Genetic effects o

Brownell WE / 1990 / Outer hair cell electromotility and otoacoustic emissions / Ear Hear 11 (2) : 82 ~ 92

Hultcrantz M / 1993 / Inner ear morphology in CBA/Ca and C57BL/ 6J mice in relationship to noise, age and phenotype / Eur Arch Otorhinolaryngol 250 (5) : 257 ~ 264

Ichimiya I / 2000 / Age-related changes in the murine cochlear lateral wall / Hear Res 139 (1-2) : 116 ~ 122

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