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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 59 - 65 (7page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.2.59
이용수
초록· 키워드
오류제보하기
Colorectal cancer is a major cause of morbidity and mortality that accounts for over 9% of all incidences of cancer.
Additionally, colorectal cancer is widely recognized as an environmental disease related to ill-defined cultural, social and lifestyle factors including physical activity, obesity, cigarette smoking and heavy alcohol consumption. Accordingly, natural phytochemicals and extracts have attracted attention because of their beneficial biological effects. Coenzyme Q10 (CoQ10) is a common supplementary medicine applied to increase bioenergetic capacity in various diseases. Therefore, in this study, we investigated whether CoQ10 treatment has any inhibitory effects and its related cellular mechanisms in human colon cancer HCT116 cells. A MTT assay revealed that CoQ10 slightly decreased the proliferation of HCT116 cells; however, glutathione- and superoxide dismutase- activity were unchanged in response to CoQ10 treatment. A DCF-DA assay revealed that CoQ10 slightly increased ROS release of HCT116 cells. However, in a nitric oxide (NO) assay, CoQ10 significantly increased NO production in a dose-dependent manner. The results of western blot analysis revealed that the protein levels of Bax, p21 and p53 were increased, whereas the protein level of Bcl2 was decreased suggesting that the CoQ10-mediated inhibitory mechanism is associated with apoptotic signaling. Taken together, our findings indicate that CoQ10 has an inhibitory effect on the growth of colon cancer cells via NO production that is associated with regulation of factors involved in apoptotic signaling including Bax, Bcl2, p21 and p53.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Abraha AM / 2016 / Apoptotic pathways as a therapeutic target for colorectal cancer treatment / World J Gastrointest Oncol 8:583~591
askaran UL / 2015 / The food supplement coenzyme Q10 and suppression of antitubercular drug-induced hepatic injury in rats: the role of antioxidant defence system, anti-inflammatory cytokine IL-10 / Cell Biol Toxicol 31:211~219
Bentires-Alj M / 2001 / Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines / Oncogene 20:2805~2813
Chen K / 2015 / New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway / Acta Pharmacol Sin 36:1074~1084
Chen ZY / 2017 / Inhibitory Effects of Probiotic Lactobacillus on the Growth of Human Colonic Carcinoma Cell Line HT-29 / Molecules 22
askaran UL / 2015 / The food supplement coenzyme Q10 and suppression of antitubercular drug-induced hepatic injury in rats: the role of antioxidant defence system, anti-inflammatory cytokine IL-10 / Cell Biol Toxicol 31:211~219
Bentires-Alj M / 2001 / Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines / Oncogene 20:2805~2813
Chen K / 2015 / New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway / Acta Pharmacol Sin 36:1074~1084
Chen ZY / 2017 / Inhibitory Effects of Probiotic Lactobacillus on the Growth of Human Colonic Carcinoma Cell Line HT-29 / Molecules 22
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