난청 동물 모델에서 신경성장인자의 청력회복에 관한 연구

김지홍; 박시내; 여상원; 김영하; 진선영; 김종훈; 조상재; 김정현; 최미영; 박경호

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자료유형: 학술저널

저자정보: 김지홍 박시내 여상원 김영하 진선영 김종훈 조상재 김정현 최미영 박경호

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제12호

발행연도: 2008.1

수록면: 1,093 - 1,098 (6page)

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Sensorineural hearing loss is caused by ototoxic drugs, radiation therapy, noise exposure and trauma, etc. They make irreversible changes in cochlear hair cells and degeneration of spiral ganglion neurons. It is known that neurotrophins and other growth factors have an important role in protectingcochlear hair cells and spiral ganglion neurons. We designed this study to analyze the effect of neurotrophins and growth factors delivered to the inner ear of deafened guinea pig. Materials and Method：Healthy 15 guinea pigs with normal Preyer’s reflex were chosen, and were made deaf by infusion of kanamycin and ethacrynic acid. Myringotomy was done to both ears, normal saline injected into the left ear, and BDNF (brainderived neurotrophic factor), GDNF (glial cell derived neurotrophic factor), NT-3 (neurotrophin-3), IGF (insulin-like growth factor), EGF (epidermal growth factor), FGF (fibroblast growth factor) were injected in the right ear. Results：Statistically significant hearing gain was obtained up to 35.00±13.78 dB in the group 1 (BDNF, GDNF, NT-3 treated group), and up to 34.0± 5.47 dB in the group 2 (IGF treated group). However, no statistically significant hearing gain was observed in the group 3 (EGF, FGF treated group). Conclusion：We observed statistically important improvement of hearing threshold in the BDNF, GDNF, NT-3 treated group and IGF treated group. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:1093-8)

#Growth factors·Guinea pig·Hearing gain.

참고문헌 (20)

참고문헌 신청

Barbacid M / 1994 / The Trk family of neurotrophic receptors / J Neurobiol 25 (11) : 1386 ~ 1403

Bredberg G / 1968 / Cellular pattern and nerve supply of the human organ of Corti / Acta Otolaryngolog 236 : 1 ~ 135

Conlon BJ / 1998 / Topical gentamicin and ethacrynic acid: Effects on cochlear function / Laryngoscope 108 (7) : 1087 ~ 1089

Glueckert R / 2008 / Deafferentiation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain

Iwai K / 2006 / Cochlear protection by local Insulin-like growth factor-1 application using biodegradable hydrogel / Laryngoscope 116 (4) : 529 ~ 533

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