지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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We evaluated the effects of single infusion of glial cell derived neurotrophic factor (GDNF) on locomotor activity in aged rats. Enhanced activity for four weeks was accompanied by an increase in sizes of the nigral dopaminergic neurons, areas of their nuclei and cytoplasm. We found that increased level of neurotrophic factors sustained in the striatum up to four weeks. There was significant rise in the level of GDNF mRNA in the striatum following GDNF treatment. These results suggest that exogenous GDNF infusion stimulates expression of itself in the brain which is related to prolonged effects of the neurotrophic factor.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Morgan, D. G / 1988 / Dopaminergic changes in the basal ganglia. A generalized phenomenon of aging in mammals / Ann. NY. Acad. Sci 515:145
Cabello, C. R / 2002 / Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy / Neuropathol. Appl. Neurobiol 28:283
Hebert, M. A / 1999 / Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study / J. Pharmacol. Exp. Ther 288:879
Darbin, O / 2012 / The aging striatal dopamine function / Parkinsonism Relat. Disord 18:426
Yue, F / 2012 / Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys / J. Neural. Transm 119:943
Cabello, C. R / 2002 / Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy / Neuropathol. Appl. Neurobiol 28:283
Hebert, M. A / 1999 / Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study / J. Pharmacol. Exp. Ther 288:879
Darbin, O / 2012 / The aging striatal dopamine function / Parkinsonism Relat. Disord 18:426
Yue, F / 2012 / Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys / J. Neural. Transm 119:943
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