후두 편평세포병변에서 Connexin 26의 발현 의의

김성렬; 조성일; 도남용; 이준한; 김건형; 임성철

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자료유형: 학술저널

저자정보: 김성렬 조성일 도남용 이준한 김건형 임성철

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제5호

발행연도: 2007.1

수록면: 442 - 447 (6page)

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Background and Objectives： (GJIC) is a mechanism for direct cell to cell signalling and is mediated by gap junctions, which consist of transmembrane proteins caled connexins (Cxs). The authors investigated the role of connexin 26 as a biomarker that helps diagnose laryngeal squamous cel lesions. Subjects and Method：Parafin-embed-ded tissue specimens from 50 patients, who were diagnosed with laryngeal invasive squamous cell carcinoma (n= 15), carcinoma in situ (n= 10), dysplasia (n= 15), and non-neoplastic epithelial hyperplasia (n= 10) between 1993 and 2005, were imunohis-tochemically stained for conexin 26 protein. Results：Intracytoplasmic positive expresion of conexin 26 was found in 100% of invasive squamous cell carcinoma and in 20% of carcinoma in situ. However, in dysplasia and hyperplasia, there were no positive expresions. Moreover, the majority of intercellular or membranous staining tended to decline in dysplasia, carcinoma in situ, and squamous cell carcinoma. Conclusion：lesions can be associated with tumorigenesis and invasion. Further studies are needed to investigate these expressions of connexin 26 and that it may represent more agresive pathology of the larynx. (Korean J Otolaryngol 2007 ;50 :442-7)

#Connexin 26·후두·편평세포종양. #Connexin 26· Larynx· Squamous cel neoplasm.

참고문헌 (18)

참고문헌 신청

/ / From oncogene to oncofetal expression : 1473 ~ 87

/ 1996 / Reduction of gap junction protein connexin 32 in rat atrophic gastric mucosa as an early event in carcinogenesis 31 (4) : 491 ~ 497

/ 1997 / Gap junction channels: New roles in disease 12 (1) : 219 ~ 231

/ 1998 / Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours 184 (1) : 37 ~ 43

/ 1998 / Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43) 58 (22) : 5089 ~ 5096

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