갑상선에 생긴 원발성 편평세포암에 관한 고찰

최정석; 임재열; 주영채; 송순욱; 김영모

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자료유형: 학술저널

저자정보: 최정석 임재열 주영채 송순욱 김영모

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제55권 제1호

발행연도: 2012.1

수록면: 26 - 29 (4page)

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Background and ObjectivesZZSquamous cell carcinoma of thyroid is uncommon and accounts for less than 1% of all primary thyroid malignancies. Clinical features mimic the natural course of anaplastic carcinoma. This study reviewed the clinical course of six cases of primary squamous cell carcinoma of thyroid. Subjects and MethodZZWe diagnosed six cases of primary squamous cell carcinoma of thyroid diagnosed from 1999 to 2006 at the College of Medicine Department of Pathology. Clinical data, treatment modality, and pathologic test results from medical records were retrospectively analyzed. ResultsZZWe found five women and one man (with the mean age of 52.1 years) with squamous cell carcinoma of thyroid. The main presenting features were abruptly enlarging neck swelling and obstructive symptom. Pre-operative needle aspiration biopsy revealed papillary carcinoma in five cases. Only one patient was diagnosed as squamous cell carcinoma through pre-operative needle aspiration biopsy. Three patients had massive adjacent organ invasion, and four patients had lymph node metastasis according to the pathology review. There were no cases of distant metastasis at the time of treatment. All patients received surgery and adjuvant therapy (radiation therapy, chemotherapy, radioiodine therapy). Three patients are still alive with a mean follow up period of 47.3 months (range, 44-49 months). The other three patients died within one year post-operatively. ConclusionZZPrimary squamous cell carcinoma of thyroid should be considered in patients diagnosed with papillary carcinoma and who exhibit aggressive clinical behavior. Complete tumor resection and radiotherapy should be performed if thyroid squamous cell carcinoma is confirmed.

#Thyroid #Squamous cell carcinoma #Aspiration biopsy

참고문헌 (10)

참고문헌 신청

Austin JR / 1996 / Thyroid cancers. II. Medullary, anaplastic, lymphoma, sarcoma, squamous cell / Otolaryngol Clin Nor-th Am 29 (4) : 611 ~ 627

Cook AM / 1999 / Squamous cell carcinoma of the thyroid: outcome of treatment in 16 patients / Eur J Surg Oncol 25 (6) : 606 ~ 609

Kebapci N / 2002 / Diffuse sclerosing variant of papillary thyroid carcinoma with primary squamous cell carcinoma / J Endocrinol Invest 25 (8) : 730 ~ 734

Korovin GS / 1989 / Squamous cell carcinoma of the thyroid: a diagnostic dilemma / Ann Otol Rhinol Laryngol 98 (1 Pt 1) : 59 ~ 65

Mai KT / 1999 / Fine needle aspiration biopsy of primary squamous cell carcinoma of the thyroid gland / Acta Cytol 43 (6) : 1194 ~ 1196