후두 편평세포병변에서 CD44v3의 발현 의의

도남용; 임성철; 조성일; 이준한; 임태승; 최성준

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자료유형: 학술저널

저자정보: 도남용 임성철 조성일 이준한 임태승 최성준

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제3호

발행연도: 2005.1

수록면: 357 - 361 (5page)

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Background and Objectives：It is known that a part of laryngeal premalignant lesions progresses to an invasive carcinoma. Despite many previous reports, conventional histology is not sufficient to predict such tumor progression. Herein, the authors investigated the role of CD44v3 as a biomarker in predicting the progression of laryngeal premalignant lesion to an inavasive cancer. Subjects and Method：Paraffin-embedded tissue specimens from 40 patients were diagnosed accordingly as laryngeal invasive squamous cell carcinoma (n=10), Carcinoma in situ (n=10), dysplasia (n=10), and hyperkeratosis (n=10) between 1993 and 2002. They were immunohistochemically stained for CD44v3 protein. Results：In invasive squamous cell carcinoma, the expression of CD44v3 was diffused and gave a strong positive stain, and in carcinoma in situ, it was diffused and gave 3+-2+ stain. However, in dysplasia and hyperkeratosis, the proportion of CD44v3 expression was decreased by 2+-1+, and 1+ -0, respectively. Conclusion：These results suggest that the expression of CD44v3 in laryngeal premalignant and malignant lesions can be associated with tumorigenesis and invasion. Those strong positive expressions of CD44v3 may represent more aggressive pathology of the larynx. (Korean J Otolaryngol 2005;48:357-61)

#CD4·후두·편평세포병변. #Antigen #CD44· Larynx #carcinoma· Squamous cell.

참고문헌 (20)

참고문헌 신청

/ / Hart IR. Isolation and characterization of humanmelanoma cell variants expressing high and low levels of CD44.Cancer Res 1991 : 6660 ~ 7

/ / Jalkanen S. Glycoprotein CD44expression and its association with survival in breast cancer. Am JPathol 1993 : 867 ~ 74

/ / Seed B. CD44is the principal cell surface receptor for hyaluronate. Cell 1990 : 1303 ~ 13

/ / and progressionto invasive squamous cell carcinoma of the upper aerodigestivetract. Am J Surg Patho 1989 : 5 ~ 16

/ / et al. Expression of CD44 variant proteins in human colorectalcancer is related to tumor progression. Cancer Res 1993 : 4654 ~ 6

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