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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 173 - 179 (7page)
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초록· 키워드
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Asian sand dust is known to promote various respiratory symptoms or disorders. For the prevention of harmful health effects by Asian sand dust, the best strategy is known to avoid or reduce exposure to the Asian sand dust. Several studies have shown that Korean red ginseng (RG) has anti-inflammatory and anti-allergic effects. The study aimed to clarify the effect of Korean red ginseng intake on lung inflammation responses to artificial sand dust (ASD) similar to Asian sand dust. BALB/c mice were divided into five groups (n=12) of control (saline), ovalbumin (OVA), OVA with ASD, OVA plus RG with ASD, and OVA plus dexamethasone (DEXA) with ASD. Histopathologic evaluation of lung was conducted. Interleukin (IL)-5, IL-12, interferon (IFN)-γ, IL-13, monocyte chemotactic protein (MCP)-1, and eotaxin within bronchoalveolar lavage (BAL) fluid were measured by ELISA. OVA+ASD group significantly increased concentrations of IL-5, IL-13, MCP-1, and eotaxin (P<0.01) compared to the control. OVA+ASD+RG group showed significant decreased levels of IL-2, IL-13, MCP-1 and eotaxin (P<0.01) compared with OVA+ASD. Between RG and DEXA treatment groups, there was no significant difference in all cytokines and chemokines. The inflammatory cells were significantly decreased in treatment groups with RG or DEXA compared to OVA+ASD group. This study suggests a beneficial effect of Korean RG administration in preventing inflammation of lung resulting from Asian sand dust.
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참고문헌 (29)
참고문헌 신청
1. [학술대회논문] - Babayigit A / 2008 / Ginseng ameliorates chronic histopathologic changes in a murine model of asthma / Allergy Asthma Proc 29 : 493 ~ 498
2. [학술지(정기간행물)] - Chen YS / 2004 / Effects of Asian dust storm events on daily mortality in Taipei, Taiwan / Environ Res 95 : 151 ~ 155
3. [학술지(정기간행물)] - Choi JC / 2001 / Chemical composition and source signature of spring aerosol in Seoul / Korea J Geophys Res 106 : 18067 ~ 18074
4. [학술지(정기간행물)] - Donaldson K / 2001 / Ultrafine particles / Occup Environ Med 58 : 211 ~ 216
5. [학술지(정기간행물)] - Echigo A / 2005 / Endospores of halophilic bacteria of the family Bacillaceae isolated from non-saline Japanese soil may be transported by Kosa event (Asian dust storm) / Saline Systems 1 : 1 ~ 13
2. [학술지(정기간행물)] - Chen YS / 2004 / Effects of Asian dust storm events on daily mortality in Taipei, Taiwan / Environ Res 95 : 151 ~ 155
3. [학술지(정기간행물)] - Choi JC / 2001 / Chemical composition and source signature of spring aerosol in Seoul / Korea J Geophys Res 106 : 18067 ~ 18074
4. [학술지(정기간행물)] - Donaldson K / 2001 / Ultrafine particles / Occup Environ Med 58 : 211 ~ 216
5. [학술지(정기간행물)] - Echigo A / 2005 / Endospores of halophilic bacteria of the family Bacillaceae isolated from non-saline Japanese soil may be transported by Kosa event (Asian dust storm) / Saline Systems 1 : 1 ~ 13
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