Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study

Tolgar Lutfi Kumral; Guven Yıldırım; Guler Berkiten; Ziya Salturk; Enes Atac; Yavuz Atar; Yavuz Uyar

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자료유형: 학술저널

저자정보: Tolgar Lutfi Kumral Guven Yıldırım Guler Berkiten Ziya Salturk Enes Atac Yavuz Atar Yavuz Uyar

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제3호

발행연도: 2016.1

수록면: 192 - 197 (6page)

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Objectives: To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. Methods: A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo group received 20×3 mg/day per oral placebo for 3 months. Tinnitus handicap inventory (THI), visual analogue scale (VAS) questionnaires and audiometric results were used to determine the effectiveness of trimetazidine treatment. Results: The study group comprised 82 tinnitus subjects, 42 (51%) of whom received trimetazidine dihydrochloride and 40 (49%) who received placebo. There was no significant difference between placebo and trimetazidine groups in THI grade and VAS (both pre- and posttreatment scores) (P>0.05) and no significant improvement was observed in subjective loudness score in either group (P>0.05). Additionally there was no significant difference between groups in pre- and posttreatment pure tone hearing thresholds at all measured frequencies (P>0.05). Conclusion: Trimetazidine dihydrochloride therapy was ineffective for relieving chronic tinnitus.

#Keywords: Tinnitus #Trimetazidine dihydrochloride #Drug treatment

참고문헌 (28)

참고문헌 신청

Jastreboff PJ / 1990 / Phantom auditory perception(tinnitus) : mechanisms of generation and perception / Neurosci Res 8(4):221~254

Coles RR / 1984 / Epidemiology of tinnitus : (1)prevalence / J Laryngol Otol Suppl 9:7~15

Mattox DE / 2006 / Assessment and management of tinnitus and hearing loss / Contin: Lifelong Learn Neurol 12(4):135~150

Konig O. / 2006 / Course of hearing loss and occurrence of tinnitus / Hear Res 221(1-2):59~64

Dobie RA / 1999 / A review of randomized clinical trials in tinnitus / Laryngoscope 109(8):1202~1211

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