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자료유형
학술저널
저자정보
Mehmet Yaman (Samsun Education and Training Hospital) Uğur Arslan (Samsun Education and Research Hospital) Hasan Ali Gümrükçüoğlu (Van 100. Yıl University) Musa Şahin (Van 100. Yıl University) Hakkı Şimşek (Van 100. Yıl University) Serkan Akdağ (Van 100. Yıl University)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.46 No.3
발행연도
2016.1
수록면
343 - 349 (7page)

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Background and Objectives: Studies reveal that the microvolt T wave alternans (MTWA) test has a high negative predictive value forarrhythmic mortality among patients with ischemic or non-ischemic cardiomyopathy. In this study, we investigate the effects oftrimetazidine treatment on MTWA and several echocardiographic parameters in patients with stable coronary artery disease. Subjects and Methods: One hundred patients (23 females, mean age 55.6±9.2 years) with stable ischemic heart disease were included inthe study group. Twenty-five age- and sex-matched patients with stable coronary artery disease formed the control group. All patientswere stable with medical treatment, and had no active complaints. Trimetazidine, 60 mg/day, was added to their current treatment for aminimum three months in the study group and the control group received no additional treatment. Pre- and post-treatment MTWAvalues were measured by 24 hour Holter testing. Left ventricular systolic and diastolic functions were assessed by echocardiography. Results: After trimetazidine treatment, several echocardiographic parameters related with diastolic dysfunction significantly improved. MTWA has been found to be significantly improved after trimethazidine treatment (63±8 μV vs. 53±7 μV, p<0.001). Abnormal MTWA waspresent in 29 and 11 patients pre- and post-treatment, respectively (p< 0.001). Conclusion: Trimetazidine improves MTWA, a non-invasive determinant of electrical instability. Moreover, several echocardiographic parametersrelated with left ventricular functions also improved. Thus, we can conclude that trimetazidine may be an effective agent to prevent arrhythmiccomplications and improve myocardial functions in patients with stable coronary artery disease.

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