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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 427 - 434 (8page)
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Chronic rhinosinusitis (CRS) is divided into CRS with nasal polyp (CRSwNP) and CRS withoutnasal polyp (CRSsNP) according to the presence of a nasal polyp. Some of the CRSwNPpatients are relatively well managed without recurrences while others are difficult due to recurrenceand refractoriness after surgical or medical treatment. Thus CRSwNP is not a singledisease but is rather considered as a disease that has a variety of disease spectrum. Various biomarkershave been proposed to distinguish endotypes of CRSwNP. CRSwNP with high tissueeosinophil infiltration with robust type 2 inflammation (e.g., IL-5) is usually associated withcomorbid asthma and is likely to recur. This type of CRSwNP is relatively common in Westerncountries. However, in Asian countries, CRSwNP is often presented as a heterogeneous diseasecomprising a mixture of type 1 (e.g., IFN-γ), type 2 and type 3 (e.g., IL-17) inflammation. In Asians, up-regulation of IL-8, IFN-γ and associated neutrophilic inflammation is prone tohave disease refractoriness. Different underlying inflammatory profile indicates different underlyingpathogenesis. Therefore, in the era of precision medicine, treatment should be basedupon according to endotype.
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참고문헌 (45)
참고문헌 신청
Fokkens WJ / 2012 / EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists / Rhinology 50(1):1~12
Ahn JC / 2016 / Prevalence and risk factors of chronic rhinosinusitus, allergic rhinitis, and nasal septal deviation : Results of the Korean National Health and Nutrition Survey 2008-2012 / JAMA Otolaryngol Head Neck Surg 142(2):162~167
Stevens WW / 2016 / Chronic rhinosinusitis with nasal polyps / J Allergy Clin Immunol Pract 4(4):565~572
Akdis CA / 2013 / Endotypes and phenotypes of chronic rhinosinusitis : A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology / J Allergy Clin Immunol 131(6):1479~1490
Agache I / 2012 / Untangling asthma phenotypes and endotypes / Allergy 67(7):835~846
Ahn JC / 2016 / Prevalence and risk factors of chronic rhinosinusitus, allergic rhinitis, and nasal septal deviation : Results of the Korean National Health and Nutrition Survey 2008-2012 / JAMA Otolaryngol Head Neck Surg 142(2):162~167
Stevens WW / 2016 / Chronic rhinosinusitis with nasal polyps / J Allergy Clin Immunol Pract 4(4):565~572
Akdis CA / 2013 / Endotypes and phenotypes of chronic rhinosinusitis : A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology / J Allergy Clin Immunol 131(6):1479~1490
Agache I / 2012 / Untangling asthma phenotypes and endotypes / Allergy 67(7):835~846
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