만성 비부비동 질환에서 비분비 단백질의 임상적 의의

최종철; 김민욱; 조민정; 윤정희; 김종엽

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자료유형: 학술저널

저자정보: 최종철 김민욱 조민정 윤정희 김종엽

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제3호

발행연도: 2007.1

수록면: 229 - 234 (6page)

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Background and Objectives：Many studies report changes in the expressions of nasal secretory proteins which play important roles in the evaluation of sinonasal mucosal status. The biomarkers in nasal secretions provide valuable information on patho-physiological status of the rhinosinusitis. We have monitored the level and ratio of nasal secretion markers, especially secretory IgA (sIgA) and lactoferrin as markers of sinonasal submucosal glands to evaluate mucosal status for chronic sinonasal diseases and allergic rhinitis. Subjects and Method：Samples were obtained with the filter paper absorption method from 20 normal healthy controls (Group I), 20 patients with chronic rhinosinusitis (Group II), 20 patients with allergic rhinitis (Group III), 20 normalized persons of chronic rhinosinusitis patients treated with antibiotics, previously (Group IV). We estimated concentrations of sIgA and lactoferrin determined by enzyme-linked immunosorbent assay method. Results：The concentration of sIgA and lactoferrin in nasal secretion showed a significant difference between the control group and other groups (p<0.05). The sIgA/ lactoferrin ratio was more highly significant in the normal group and normalized in chronic rhinosinusitis patients treated with antibiotics (Group IV) than other groups (p<0.05). Conclusion：In this study, sIgA and lactoferrin are useful secretion markers oring and assessing the conditions of the sinonasal mucosal diseases. (Korean J Otolaryngol 2007 ;50 :229-34)

#분비 단백질·분비형 IgA·락토페린·만성 비부비동염. #Secretory protein· Secretory IgA· Lactoferrin· Chronic rhinosinusitis.

참고문헌 (17)

참고문헌 신청

/ / Lysozyme and lactoferrinin human maxillary sinus mucosa during chronic sinusitis : 133 ~ 9

/ / The effect of an orally administered proteolytic enzyme on the elasticityand viscosity of nasal mucus : 355 ~ 9

/ 1997 / A bactericidal effect for human lactoferrin 197 : 263 ~ 265

/ 1997 / Quantitative study of nasal secretorycells in normal subjects and patients with chronic sinusitis 107 : 1515 ~ 1518

/ 1998 / Inflammatory mediators in naturally occurring rhinitis 28 (2) : 220 ~ 227

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