Ki67 Antigen as a Predictive Factor for Prognosis of Sinonasal Mucosal Melanoma

김동규; 김대우; 김시환; 김동영; 이철희; 이재서

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자료유형: 학술저널

저자정보: 김동규 김대우 김시환 김동영 이철희 이재서

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제1권 제4호

발행연도: 2008.1

수록면: 206 - 210 (5page)

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Objectives. Sinonasal mucosal melanoma is a rare and aggressive disease. The aim of this study was to analyze the clinical features of patients with sinonasal mucosal melanoma and to determine the role of Ki67 antigen as a predictor of prognosis in sinonasal mucosal melanoma. Methods. This was a retrospective case- series study at a single institution, an academic tertiary referral center. From 1995 to 2007, 27 patients with sinonasal mucosal melanoma were reviewed retrospectively, and the expression of Ki67 antigen was assessed by immunohistochemistry. Results. The overall 5-yr survival rate was 33.9%. No significant differences were observed in 5-yr survival according to age, sex, stage, or the presence of melanin. The rates of local failure, regional failure, and distant failure were 37.0%, 14.8%, and 11.1%, respectively. Patients with spindle or mixed cell types had better prognoses than those with other cell types. At a cut-off value of 35%, patients with lower Ki67 scores showed better survival than those with higher Ki67 scores. Conclusion. The presence of spindle or mixed cell types may indicate a better prognosis than other cell types. Ki67 immunostaining may be a useful predictor of prognosis in patients with mucosal malignant melanoma of the sinonasal tract.

#Ki67 antigen #Melanoma #Nasal cavity #Paranasal sinuses

참고문헌 (19)

참고문헌 신청

Batsakis JG / 1982 / The pathology of head and neck tumors: mucosal melanomas, part 13 / Head Neck Surg 4 (5) : 404 ~ 418

Ben-Izhak O / 2002 / Ki67 antigen and PCNA proliferation markers predict survival in anorectal malignant melanoma / Histopathology 41 (6) : 519 ~ 525

Berthelsen A / 1984 / Melanomas of the mucosa in the oral cavity and the upper respiratory passages / Cancer 54 (5) : 907 ~ 912

Chiu NT / 1996 / Melanoma of oronasal mucosa. Populationbased analysis of occurrence and mortality / Arch Otolaryngol Head Neck Surg 122 (9) : 985 ~ 988

Cuevas E / 1993 / Immunohistochemical detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues / J Pathol 169 (4) : 477 ~ 478

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