만성 비부비동염 환자에서 식염수 세척이 점액분비에 미치는 영향

김정수; 최영준; 손정호; 이창민; 이유정; 장현욱

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자료유형: 학술저널

저자정보: 김정수 최영준 손정호 이창민 이유정 장현욱

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제9호

발행연도: 2005.1

수록면: 1,122 - 1,125 (4page)

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연구주제

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연구배경

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연구방법

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Background and Objectives：Various saline solution formulae for nasal irrigation have been used frequently in patients with rhinosinusitis. However, there are not enough scientific evidences supporting the effect of irrigation of the nose with saline solution. We investigated the effects of saline irrigation on mucus secretion, subjective symptoms, and nasal cavity air-space volume changes in patients with rhinosinusitis. Subjects and Method：The nasal cavities of patients with rhinosinusitis were washed with 0.9%, 3%, and 6% of saline solutions consecutively with about 10 minute intervals. Lavage fluids were collected from the ipsilateral sides to determine the concentrations of mucin and lysozyme. Patients recorded subjective symptoms and each patient’s nasal cavity air-space volume was assessed by acoustic rhinometry after each irrigations. Results：The sensation of rhinorrhea, pain, and nasal blockage were increased as the concentration of saline increased. The concentrations of mucin increased with the increasing concentration of saline solution. However, the concentration of lysozyme decreased with the increase in the concentration of saline solution. Futhermore, hypertonic saline solution (6%) decreased the air-space volume significantly. Conclusion：The saline solution induces mucin secretion but not lysozyme secretion in patients with chronic rhinosinusitis. These changes in the secretion pattern may change the physical properties of mucus. The hypertonic saline solution may increase the edema of nasal cavity and decrease air-space volume.

#부비동염·점액·점소. #Sinusitis·Mucus·Mucins.

참고문헌 (13)

참고문헌 신청

/ 1953 / Applied physiology of the nose

/ 1991 / Control of mucus secretion in airways 58 : 1 ~ 8

/ 1992 / Transient cholinergicglycoconjugate secretion from swine tracheal submucosal gland cells 262

/ 1996 / A medical or surgical disease : 1 ~ 9

/ 1996 / Inhalation of hypertonic saline aerosol enhances mucociliary clearancein asthmatic and healthy subjects 9 : 725 ~ 32

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