흰쥐 내임파관에서의 라이소자임과 락토페린의 분포와 발현

최석찬; 안정윤; 이형준; 강성호; 김보형; 임대준; 도현진; 정영선

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자료유형: 학술저널

저자정보: 최석찬 안정윤 이형준 강성호 김보형 임대준 도현진 정영선

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제6호

발행연도: 2009.1

수록면: 482 - 485 (4page)

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Background and Objectives：Secretory activity, particularly of antibacterial agents such as lysozyme and lactoferrin, is an important aspect of the mucosal defense mechanism. The development of these agents may have a direct bearing on the susceptibility of the mucosa to infection. The antibacterial secretory enzymes such as lysozymes and lactoferrins are found in various mucosal tissues, and it has been suggested that these enzymes contribut to the defense against local mucosal infection. Specifically, lysozyme and lactoferrin are important components of innate immunity against pathogens at mucosal surfaces. The purpose of this study is to identify the distribution and expression of lysozyme, lactoferrin in endolymphatic duct of rat. Materials and Method： Normal rats (129P3/J, 10 cases) were used for this study. The expression level and distribution of lysozyme mRNA were analyzed by RT-PCR and quantitative image analysis. Results：The expression of lysozyme and lactoferrin mRNA in endolymphatic ducts of rats was compared by quantitative image analysis. The results indicate that the relative expression of lysozyme mRNA resulted as 2.5 times greater than that of lactoferrin mRNA. Conclusion：The distribution and expression of lysozyme and lactoferrin in the endolymphatic duct of rat were identified. The study suggests that innate immunity such as lysozyme and lactoferrin are important components of defense mechanisms along with mucociliary clearance. Additionally, the authors think that the activity of lysozymes is more effective than that of lactoferrin in the endolymphatic duct of rat.

#라이소자임·락토페린·내임파관·흰쥐 #Lysozyme·Lactoferrin·Endolymphatic duct·Rat

참고문헌 (17)

참고문헌 신청

Arnold RR / 1977 / A bactericidal effect for human lactoferrin / Science 197 (4300) : 263 ~ 265

Davis B / 1991 / Neural regulation of lysozyme secretion from tracheal submucosal glands of ferrets in vivo / J Appl Physiol 71 (3) : 939 ~ 944

Fleming A / 1922 / On remarkable bacteriolytic element found in tissues and secretions / Proc R Soc Ser B (93) : 306 ~ 317

Giebink GS / 1985 / Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion / Ann Otol Rhinol Laryngol 94 (4)

Hanamure Y / 1986 / Normal distribution of lysozyme and lactoferrinsecreting cells in the chinchilla tubotympanum / Am J Otolaryngol 7 (6) : 410 ~ 425

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