Respiratory Syncytial Virus에 의한 호흡상피세포 감염 시 Polymeric Immunoglobulin Receptor가 호산구의 탈과립에 미치는 영향

황준연; 조중생; 김재명; 김성완; RobertoGarofalo

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자료유형: 학술저널

저자정보: 황준연 조중생 김재명 김성완 RobertoGarofalo

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제46권 제6호

발행연도: 2003.1

수록면: 481 - 487 (7page)

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Background and Objectives：The presence of eosinophil-specific cytotoxic mediators in nasopharyngeal secretions of infants induced airway inflammation and the associated epithelial damage. A recent report demonstrated that RSV-infected respiratory cells induce eosinophil degranulation by a CD11b/CD18-dependent, ICAM-1-independent mechanism. However, the molecule on the epithelial cell membrane involved in the receptor-mediated degranulation of eosinophils after RSV infection has not been clearly identified. Materials and Method：We investigated the efect of RSV infection on the expresion of pIgR on A549 cells and blocking of the RSV-infected cell induced eosinophil degranulation with monoclonal antibodies of the pIgR. Results：After 24h of RSV infection, A549 cells expressed pIgR remarkably whereas pIgR was hardly expressed by the uninfected cels in flow cytometry and in the semi-quantitative RT-PCR. CD11b/CD18 on eosinophils was highly expresed by the RSV con-ditioned media. Purified eosinophils cocultured with the RSV-infected A549 cells showed approximately eightfold increase in ECP in the isotype control, compared with the control and that was blocked by treatment of anti-pIgR monoclonal antibody. Conclusion：It is strongly sugested that pIgR expression in the epithelial cells may be a key factor for eosinophil degranula-(Korean J Otolaryngol 2003 ;46 :481-7)

#Respiratory Syncytial Viruses·Polymeric immnoglobulin receptors·호산구. #Respiratory syncytial viruses·Polymeric immunoglobulin receptors·Eosinophils.

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