지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 283 - 289 (7page)
이용수
초록· 키워드
오류제보하기
Human Respiratory Syncytial virus (hRSV) is a leading cause of severe lower respiratory tract diseases in the pediatric population.hRSV frequently causes severe morbidity and mortality in high risk groups including infants with congenital heart disease and the immunosuppressed patients. Although hRSV is recognized as a major public health threat and economic burden worldwide, there is no licensed vaccine and effective therapeutic agent. Viral nonstructural (NS) proteins have been known to play multiple functions for efficient viral replication and pathogenesis. Especially, diverse functions of influenza A virus NS1 have been extensively studies. Recent studies demonstrated that NS1 and NS2 of RSV also exert diverse functions to modulate cellular environment and antiviral immune responses. Since NS proteins of RSV are required for efficient replication and pathogenesis, NS mutant viruses have been tested as live-attenuated vaccines. This review will outline the recent progress in understanding the various functions of RSV NS1 and NS2.
목차
1. RSV 감염의 임상적 특징 및 감염에 대한 면역반응
2. RSV 바이러스 NS1/NS2 단백질의 개요
3. RSV NS1/NS2에 의한 인터페론 신호전달체계의 조절
4. NS1/NS2에 의한 능동면역(adaptive immunity)의 조절
5. NS1과 NS2의 면역반응 조절 이외의 기능
CLOSING REMARK
REFERENCES
참고문헌 (41)
참고문헌 신청
1. [학술지(정기간행물)] - Hall CB1. / 2009 / The burden of respiratory syncytial virus infection in young children / N Engl J Med 360 : 588 ~ 598
2. [학술지(정기간행물)] - Glezen WP. / 1986 / Risk of primary infection and reinfection with respiratory syncytial virus / Am J Dis Child 140 : 543 ~ 546
3. [학술지(정기간행물)] - Pastey MK. / 1995 / Nucleotide sequence analysis of the non-structural NS1(1C)and NS2(1B)protein genes of bovine respiratory syncytial virus / J Gen Virol 76 : 193 ~ 197
4. [학술지(정기간행물)] - Teng MN. / 2012 / The non-structural proteins of RSV : targeting interferon antagonists for vaccine development / Infect Disord Drug Targets 12 : 129 ~ 137
5. [학술지(정기간행물)] - Thompson WW. / 2003 / Mortality associated with influenza and respiratory syncytial virus in the United States / JAMA 289 : 179 ~ 186
2. [학술지(정기간행물)] - Glezen WP. / 1986 / Risk of primary infection and reinfection with respiratory syncytial virus / Am J Dis Child 140 : 543 ~ 546
3. [학술지(정기간행물)] - Pastey MK. / 1995 / Nucleotide sequence analysis of the non-structural NS1(1C)and NS2(1B)protein genes of bovine respiratory syncytial virus / J Gen Virol 76 : 193 ~ 197
4. [학술지(정기간행물)] - Teng MN. / 2012 / The non-structural proteins of RSV : targeting interferon antagonists for vaccine development / Infect Disord Drug Targets 12 : 129 ~ 137
5. [학술지(정기간행물)] - Thompson WW. / 2003 / Mortality associated with influenza and respiratory syncytial virus in the United States / JAMA 289 : 179 ~ 186
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