Cisplatin이독성의 NO에 의한 매개:기니픽에서 L-NAME과 MK-801을 이용한 연구

이정구; 정상용; 오양희; 전상준; 오충훈

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자료유형: 학술저널

저자정보: 이정구 정상용 오양희 전상준 오충훈

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제45권 제8호

발행연도: 2002.1

수록면: 741 - 746 (6page)

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📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

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Background & Objectives：Nitric oxide has been sugested to play an important role in the pathogenesis of cisplatin ototo-(NG-Nitroarginine Methyl Ester) is an inhibitor of nitric oxide synthase. MK-801 (Dizocilpine Maleate) is a NMDA receptor antagonist. To evaluate a role of nitric oxide in cisplatin ototoxicity, we investigated whether L-NAME and MK-801 can block the cisplatin ototoxicity in guinea pigs. Materials & Method：In the Group 1, normal saline was in-jected intraperitonealy as a control group. Group 2, 3, 4, and 5 were injected intraperitonealy as described in the folowing：Group 2, cisplatin only； + cisplatin；Group 4, MK-801+ cisplatin；Group 5, L-NAME+ MK-801+ cis-platin. Using an auditory brainstem response, hearing threshold was tested before cisplatin administration and 5 days after cisplatin injection in each group. The morphological changes of the cochlea were observed by scanning electron microscopy. Results：In the Group 2, a significant hearing loss was observed comparing to Group 1. In contrast, Group 3, 4, and 5 did distorsion and loss of stereocilia of the hair cells. However, the Group 1, 3, 4, and 5 demonstrated well preserved cochlear hair cell morphology. Conclusion：Hearing loss induced by ototoxicity of cisplatin was prevented by L-NAME and MK-801. This study suggests that NO may mediate cisplatin ototoxicity. (Korean J Otolaryngol 2002;45:741-6)

#Cisplatin·NG-Nitroarginine methyl ester·Dizocilpine maleate·Nitric oxide.

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