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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
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- 1 - 5 (5page)
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Human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS). Anti- HIV agents targeting various steps in HIV life cycle have been developed; however, so far, no effective drugs have been found. We show here that a peptide isolated from Spirulina maxima (SM-peptide) inhibits HIV-1 infection in a human T cell line MT4. SM-peptide inhibited HIV-1IIIB-induced cell lysis with a half-maximal inhibitory concentration (IC50) of 0.691 mM, while its 50 % cytotoxic concentration (CC50) was greater than 1.457 mM. Furthermore, the SMpeptide inhibited the HIV-1 reverse transcriptase activity and p24 antigen production. This suggests that SM-peptide is a novel candidate peptide, which may be developed as a therapeutic agent for acquired immunodeficiency syndrome patients.
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참고문헌 (11)
참고문헌 신청
Ay E / 2013 / Epigenetics of HIV infection : promising research areas and implications for therapy / AIDS Rev 15:181~188
Broder S / 2010 / The development of antiretroviral therapy and its impact on the HIV-1/ AIDS pandemic / Antiviral Res 85:1~18
Lifson MA / 2016 / Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring / Adv Drug Deliv Rev 103:90~104
Migueles SA / 2015 / Success and failure of the cellular immune response against HIV-1 / Nat Immunol 16:563~570
Ngo DH / 2012 / Biological activities and potential health benefits of bioactive peptides derived from marine organisms / Int J Biol Macromol 51:378~383
Broder S / 2010 / The development of antiretroviral therapy and its impact on the HIV-1/ AIDS pandemic / Antiviral Res 85:1~18
Lifson MA / 2016 / Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring / Adv Drug Deliv Rev 103:90~104
Migueles SA / 2015 / Success and failure of the cellular immune response against HIV-1 / Nat Immunol 16:563~570
Ngo DH / 2012 / Biological activities and potential health benefits of bioactive peptides derived from marine organisms / Int J Biol Macromol 51:378~383
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