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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 284 - 296 (13page)
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Objectives: The purpose of this study was to examine the effects of Ohmae-hwan (OMH) and Mume Fructus (MF) on inflammatory bowel disease (IBD).
Methods: Mice were divided into 4 groups: a normal group, control group, MF group, and OMH group. Three groups, excluding the normal group, were fed a 5% solution of dextran sulfate sodium (DSS) in water for 10 days to induce inflammatory bowel disease. From the fourth day of DSS treatment, the control group was given distilled water only, the MF group was given MF powder in distilled water, and the OMH group was given dried OMH extract powder in distilled water for 7 days.
Results: For each animal, changes in body weight, colon length, and component levels in blood and colon tissues after each treatment were noted. The weight in the control group and MF group decreased slightly compared with that in the OMH group, and the colon length in the MF group and OMH group was more than that in the control group. TNF-α and WBC were decreased in both the MF group and the OMH group. RBC was increased in the OMH group, like in the normal group, compared with the control group and MF group. Hb and PLT of each group were not significantly different. Regarding changes in the colon tissues, both the MF group and OMH groups recovered similar to the normal group.
Conclusions: Thus, treatment with OMH and MF seems to be effective against inflammatory bowel disease, and OMH is likely to increase body weight and induce RBC recovery better than MF.
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참고문헌 (32)
참고문헌 신청
Cooper HS / 1993 / Clinicopathologic study of dextran sulfate sodium experimental murine colitis / Lab invest 69 (2) : 238 ~ 249
Ekstrom GM / 1998 / Oxazolone induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acid / Scand J Gastreoenterol 33 : 174 ~ 179
Fedorak RN / 2000 / Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease / Gastroenterology 119 : 1473 ~ 1482
Hanada T / 2002 / Regulation of cytokine signaling and inflammation / Cytokine Growth Factor Rev 3 : 413 ~ 421
Ishiguro K / 2006 / Paeonol Attenuates TNBS-induced colitis by inhibiting NF-B and STAT1 transactivation / Toxicology and Applied Pharmacology 217 (1) : 35 ~ 42
Ekstrom GM / 1998 / Oxazolone induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acid / Scand J Gastreoenterol 33 : 174 ~ 179
Fedorak RN / 2000 / Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease / Gastroenterology 119 : 1473 ~ 1482
Hanada T / 2002 / Regulation of cytokine signaling and inflammation / Cytokine Growth Factor Rev 3 : 413 ~ 421
Ishiguro K / 2006 / Paeonol Attenuates TNBS-induced colitis by inhibiting NF-B and STAT1 transactivation / Toxicology and Applied Pharmacology 217 (1) : 35 ~ 42
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