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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 821 - 832 (12page)
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Purpose : This study is to observe the nephroprotective effects of the traditional prescription, Daebuncheong-eum (DBCE). The DBCE has been generally used for treating various renal diseases, including renal failure.
Methods : At first three different dosages of DBCE extract were orally administered once a day for 28 days. At 23th day after DBCE extract treatment, cisplatin has been treated. And then, 5 days after cisplatin treatment. all the rats (6 groups, each of 8 rats per group) were checked in the present study. The changes on the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed.
Results : Cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of DBCE extracts.
Conclusion : This study suggest that DBCE extracts showed favorable effects on the cisplatin-induced rat ARF.
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참고문헌 (30)
참고문헌 신청
Ahn H / 1994 / Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines / J Urol 151 : 263 ~ 267
Cetin R / 2006 / Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods / J Appl Toxicol 26
Davis CA / 2001 / Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide / J Am Soc Nephrol 12 : 2683 ~ 2690
Durmus A / 2005 / Effect of valsartan on erythropoietin and hemoglobin levels in stage III-IV chronic kidney disease patients / Int J Clin Pract 59 : 1001 ~ 1004
El-Sayed el-SM / 2008 / Protective effect of captopril against Cisplatin- induced nephrotoxicity in rats / Pak J Pharm Sci 21 : 255 ~ 261
Cetin R / 2006 / Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods / J Appl Toxicol 26
Davis CA / 2001 / Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide / J Am Soc Nephrol 12 : 2683 ~ 2690
Durmus A / 2005 / Effect of valsartan on erythropoietin and hemoglobin levels in stage III-IV chronic kidney disease patients / Int J Clin Pract 59 : 1001 ~ 1004
El-Sayed el-SM / 2008 / Protective effect of captopril against Cisplatin- induced nephrotoxicity in rats / Pak J Pharm Sci 21 : 255 ~ 261
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