지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 620 - 630 (11page)
이용수
초록· 키워드
오류제보하기
Purpose : The object of this study was to observe the nephroprotective effects of Manjeonmoktong-san(MJMTS), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure.
Methods : At first, three different dosages of MJMTS extract were orally administered once a day for 28 days. On the 23rd day after MJMTS extract treatment, cisplatin was treated. Then, 5 days after cisplatin treatment, all the rats (6 groups of 8 rats each) were checked in the present study. The changes to the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed.
Results : It showed dramatical decrease on the body weight, increase of serum BUN and creatinine levels were detected in cisplatin control as compared with intact control. In addition marked increase of kidney MDA contests and decrease of kidney GSH contents were also detected in cisplatin control as compared with intact control. it means that cisplatin induced ARF are induced by oxiidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of MJMTS extracts.
Conclusion : This study suggests that MJMTS extracts have favorable effects on the cisplatin-induced rat ARF.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Ahn H / 1994 / Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines / J Urol. 151 : 263 ~ 267
Baldew GS / 1990 / Selective reduction of cis-diamminedichloroplatinum(Ⅱ) nephrotoxicity by ebselen / Cancer Res 50 : 7031 ~ 7036
Cetin R / 2006 / Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods / Appl Toxicol. 26 :
Dahle LK / 1962 / The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters / Arch Biochem Biophys 98 : 221 ~ 253
Davis CA / 2001 / Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide / J Am Soc Nephrol 12 : 2683 ~ 2690
Baldew GS / 1990 / Selective reduction of cis-diamminedichloroplatinum(Ⅱ) nephrotoxicity by ebselen / Cancer Res 50 : 7031 ~ 7036
Cetin R / 2006 / Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods / Appl Toxicol. 26 :
Dahle LK / 1962 / The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters / Arch Biochem Biophys 98 : 221 ~ 253
Davis CA / 2001 / Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide / J Am Soc Nephrol 12 : 2683 ~ 2690
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
澤瀉散 抽出物이 Cisplatin으로 誘發된 흰쥐의 急性腎不全에 미치는 影響
대한한방내과학회지
2009 .01
-
消腫調脾順氣湯이 Cisplatin으로 誘發된 흰쥐의 急性腎不全에 미치는 영향
대한한방내과학회지
2011 .01
-
五皮散이 Cisplatin으로 誘發된 흰쥐의 急性腎不全에 미치는 影響
대한한방내과학회지
2010 .01
-
大分淸飮이 Cisplatin으로 誘發된 흰쥐의 急性腎不全에 미치는 影響
대한한방내과학회지
2009 .01
-
Effects of Human Adipose-Derived Stem Cells in Regenerating the Damaged Renal Tubular Epithelial Cells in an Animal Model of Cisplatin-Induced Acute Kidney Injury
Childhood Kidney Diseases
2015 .01
-
Cisplatin의 신장독성에 관한 연구 2. Cisplatin의 신장근위세뇨관 glucose 이동에 미치는 영향과 몇 가지 약물들의 독성경감효과 ( Studies on the Cisplatin Nephrotoxicity 2. Effects of cisplatin on the renal proximal tubular glucose transport and alleviating effects of some drugs on the renal toxicity of cisplatin )
한국환경성돌연변이·발암원학회지
1994 .03
-
Protective effect of ginsenosides Rk3 and Rh4 on cisplatin-induced acute kidney injury in vitro and in vivo
Journal of Ginseng Research
2017 .07
-
Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats
Laboratory Animal Research
2014 .12
-
Preventive effect of fermented black ginseng against cisplatin-induced nephrotoxicity in rats
Journal of Ginseng Research
2017 .04
-
Effect of bioconversioned ginseng on cisplatin-induced nephrotoxicity and adenine-induced renal failure in rats
대한약학회 학술대회
2002 .01
-
Protective Effects of Vitamin C on Cisplatin Naphrotoxicity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1994 .01
-
Cisplatin과 보정방암탕에 의한 백서 사구체 혈관사이세포의 세포사멸 기전 연구
동의생리병리학회지
2013 .02
-
葛根 추출물이 cisplatin에 의해 유도된 rat mesangial cell의 apoptosis에 미치는 영향
동의생리병리학회지
2010 .04
-
Oyster mushroom extract protects antioxidant defence system in cisplatin induced nephrotoxicity in mice
Oriental pharmacy and experimental medicine
2004 .01
-
A New Rat Model of Cisplatin-induced Neuropathic Pain
The Korean Journal of Pain
2015 .01
-
Antioxidative Effects of Lycium chinense Miller on Cisplatin-induced Nephrotoxicity in Rats
대한한방내과학회지
2014 .01
-
The Effect of Irradiation and Cis-diamminedichloroplatinum(II) in the Rat Brain : Analysis of Histopathology at 3 and 6 Months after Treatment
Radiation oncology journal : ROJ
1998 .01
-
황금약침액(黃芩藥鍼液)이 Cisplatin에 의해 유발된 급성신불전(急性腎不全)에 미치는 영향
대한침구의학회지
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0