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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 600 - 611 (12page)
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초록· 키워드
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Purpose : This study was to observe the nephroprotective effects of the traditional prescription, Opi-san(OPS). OPS has been generally used for treating various edematous renal diseases, including acute renal failure.
Methods : Three different dosages of OPS extracts were administered once a day for 28 days (5 mg/kg, single intraperitoneally administered). On the 23rd day after OPS extract treatment, cisplatin was treated. All the rats (6 groups of 8 rats each) were checked as follows. Changes of body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes to the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg, of which the effects on cisplatin-induced acute renal failures were already confirmed.
Results : Cisplatin-induced ARF were induced by oxidative stress and related lipid peroxidation in the present study. However, these ARF and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of OPS extracts except in the 100 mg/kg treated group. The effects of OPS extracts at 500 mg/kg were similar to those of 100 mg/kg of captopril.
Conclusion : This study suggests that OPS extracts 500 mg/kg showed favorable effects on the cisplatin-induced rat’s ARF as similar to 100 mg/kg of captopril.
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참고문헌 (29)
참고문헌 신청
Ahn H / 1994 / Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines / J Urol. 151 : 263 ~ 267
Cetin R / 2006 / Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods / J Appl Toxicol. 26
Davis CA / 2001 / Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide / J Am Soc Nephrol 12 : 2683 ~ 2690
Durmus A / 2005 / Effect of valsartan on erythropoietin and hemoglobin levels in stage Ⅲ-Ⅳ chronic kidney disease patients / Int J Clin Pract 59 : 1001 ~ 1004
E.Braunwald / 2003 / Harrison's Principles of Internal Medicine / MIP : 1589 ~ 1598
Cetin R / 2006 / Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods / J Appl Toxicol. 26
Davis CA / 2001 / Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide / J Am Soc Nephrol 12 : 2683 ~ 2690
Durmus A / 2005 / Effect of valsartan on erythropoietin and hemoglobin levels in stage Ⅲ-Ⅳ chronic kidney disease patients / Int J Clin Pract 59 : 1001 ~ 1004
E.Braunwald / 2003 / Harrison's Principles of Internal Medicine / MIP : 1589 ~ 1598
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