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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 543 - 553 (11page)
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Objective : The goal of this study was to determine the anti-asthma mechanism of SF on TNF-α induced activation on A549 (human typeⅡ-like epithelial) cells. Using oligonucleotide microarray, we sought to establish the molecular mechanism of the protective effects of SF on A549 cells.
Material & Methods : Cells were cultured in three different conditions: 1) negative control group was cultured in normal condition of DMEM, 2) positive control group was activated with TNF-α, IL-4, and IL-1β, and 3) SF treated group was previously treated with 0.1㎍/㎖ SF after TNF-α, IL-4, and IL-1 activation. Cells of positive control and SF treated groups were cultured for 30 min, 1hr, 3hr and 6hr.
Results : The comparative analysis of the gene expression profile revealed that proinflammatory cytokines such as IL1F8, IL1F9, IL1R1, IL1RN, IL1RAPL1, IL8, TNFRSF4, TNFSF10c, TNFSF13, TRAF5, and TRAF7 and inflammation-related genes including MMP2, MMP11, MMP14, MMP15, MMP16, MMP19, MMP25, and MMP27 were down regulated with SF treatment. Cell adhesion molecule genes such as ITGB1, ITGBL1, selectin P ligand, selectin E, ICAM2, ICAM3, VCAM1, PECAM, FCER1G and MMP28 genes were also down-regulated in SF treated A549 cells.
Conclusion : These results suggest that the anti-asthmatic effects of SF could be mediated by regulating specific genes related with cell adhesion, proinflammatory cytokine and inflammation-related genes in A549 cells.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ 2005 / 2005 한국 기관지천식 치료지침. The Korean academy of asthma, allergy & clinical immunology. 군자출판사. 2005
Alexis NE / 2001 / Blunting airway eosinophilic inflammation results in a decreased airway neutrophil response to inhaled LPS in patients with atopic asthma: a role for CD14
Argenbright LW / 1992 / Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman
Busse WW / 2003 / Mechanisms of asthma / J Allergy Clin Immunol 111 (3) : 799 ~ 804
Kikuchi I / 2006 / Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils / Am J Respir Cell Mol Biol 34 (6) : 760 ~ 765
Alexis NE / 2001 / Blunting airway eosinophilic inflammation results in a decreased airway neutrophil response to inhaled LPS in patients with atopic asthma: a role for CD14
Argenbright LW / 1992 / Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman
Busse WW / 2003 / Mechanisms of asthma / J Allergy Clin Immunol 111 (3) : 799 ~ 804
Kikuchi I / 2006 / Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils / Am J Respir Cell Mol Biol 34 (6) : 760 ~ 765
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