지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Objectives : Peroxynitrite (ONOO-), superoxide anion radical (?O2-) and nitric oxide (NO) are cytotoxic because they can oxidize several cellular components such as proteins, lipids and DNA. They have been implicated in the aging process, and age-related diseases such as Alzheimer's disease, rheumatoid arthritis, cancer and atherosclerosis. The aim of this study was to investigate Sabohwan's activity for scavenging ONOO- and its precursors, NO and ?O2-.Methods : For this study, the fluorescent probes, namely 2’,7’-dichlorodihydrofluorescein diacetate (DCFDA), 4,5-diaminofluorescein (DAF-2) and dihydrorhodamine 123 (DHR 123) were used. Results : Sabohwanblocked tert-butylhydroperoxide (t-BHP)-induced cell death in a dose-dependent fashion. It scavenged t-BHP-induced ONOO-, NO and ?O2- in YPEN cells. Sabohwan inhibited the generation of ONOO-, NO and ?O2- in the lipopolysaccharide (LPS)-treated mouse kidney postmitochondria both in vitro and in vivo. The lipid peroxide level increased and glutathione level decreased in the LPS-treated mice, whereas the ones in the Sabohwanadministered group among the LPS-treated mice reversed toward their natural levels.Conclusions : These results suggest that Sabohwanis an effective ONOO-, ?O2- and NO scavenger, and thereby it might have a potential role as a therapy against the aging process and age-related diseases.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 1951 / Protein measurement with folin phenol reagent.J Biol Chem 193 : 265 ~ 75
/ 1959 / Tissue sulfhydryl group.Arch Biochem Biophys 82 : 70 ~ 7
/ 1973 / Distribution of enzymes that catalyze reactions of glutathione with α : 756 ~ 69
/ 1979 / Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction.Anal Biochem 95 : 351 ~ 8
/ 1983 / Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein fluorescent assay.Anal Biochem 134 : 111 ~ 6
/ 1959 / Tissue sulfhydryl group.Arch Biochem Biophys 82 : 70 ~ 7
/ 1973 / Distribution of enzymes that catalyze reactions of glutathione with α : 756 ~ 69
/ 1979 / Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction.Anal Biochem 95 : 351 ~ 8
/ 1983 / Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein fluorescent assay.Anal Biochem 134 : 111 ~ 6
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
三精丸의 Peroxynitrite 제거 효과
대한한방내과학회지
2006 .01
-
五子丸의 Peroxynitrite 제거 작용
대한한방내과학회지
2005 .01
-
葫蘆巴추출물의 Peroxynitrite 제거 및 염증 인자 단백질 억제 효과
대한한방내과학회지
2006 .01
-
상심자추출물의 Peroxynitrite억제 및 염증 촉진 인자 제어 효과
동의생리병리학회지
2008 .01
-
覆盆子의 세포내 ROS, ONOO- 생성 및 Ca2+ 증가 억제에 의한 혈관내피세포 보호작용
대한한방내과학회지
2005 .01
-
노봉방(露蜂房)이 t-butylhydroxyperoxide에 의한 Peroxynitrite 생성과 염증성 단백질 발현에 미치는 영향
동의생리병리학회지
2007 .01
-
Inflammatory Large Bowel Disease due to Helicobacter hepaticus infection in BALB/cA-Hfh11nu Mice
Laboratory Animal Research
2002 .09
-
Overexpression of hARD1235 accelerates Tumorigenesis in APCMIN/+Mice
한국실험동물학회 학술발표대회 논문집
2009 .04
-
Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
오정환(五精丸)이 ob/ob mouse에서 Redox Status 및 NF-${\kappa}B$ Signaling에 미치는 영향
동의생리병리학회지
2008 .01
-
露蜂房의 Peroxynitrite 제거 효과
대한한의학회지
2006 .06
-
Peroxynitrite Scavenging Activity of Sinapic Acid
대한약학회 학술대회
2002 .01
-
Effect of Korean Red Ginseng Extract on Cell Death Responses in Peroxynitrite-Treated Keratinocytes
Journal of Ginseng Research
2010 .09
-
보골지의 peroxynitrite 제거 기준
대한한방내과학회지
2004 .01
-
解毒四物湯이 LPS 유도 ICR mouse의 산화스트레스 및 고지혈증에 미치는 효과
대한한의학회지
2016 .03
-
In Vitro Antioxidant Activity of Some Selected Prunus Species in Korea
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
고농도 포도당에 노출된 마우스 신장상피세포에서 桑枝의 산화 스트레스 억제 효과
대한한방내과학회지
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0