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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제39권 제1호
- 발행연도
- 2009.1
- 수록면
- 77 - 86 (10page)
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초록· 키워드
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Purpose: Recombinant human bone morphogenetic protein-2(rhBMP-2) has been evaluated as potential candidates for periodontal and bone regenerative therapy. In spite of good prospects in BMP applications, there is economically unavailable for clinical use in dental area. The purpose of this study was to evaluate the osteogenic effect of rhBMP-2 produced by E.coli expression system.
Materials and methods: Eight-mm critical-size calvarial defects were created in 48 male Sprague-Dawley rats. The animals were divided into 6 groups of 8 animals each. Each group received one of the following: Negative control(sham-surgery control), positive control(absorbable collagen sponge(ACS) alone) and experimental(ACS loaded with rhBMP-2). Defects were evaluated by histologic and histometric parameters following 2- and 8-week healing intervals.
Results: The experimental group showed significant defect closure at 2 and 8weeks than the sham surgery and positive control groups. Moreover, the experimental group showed significantly greater new bone and augmented area than the other groups at both 2 and 8weeks.
Conclusion: rhBMP-2 produced by E.coli expression system may be effective for bone regeneration. (J Korean Acad Periodontol 2009;39:77-86)
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alam I / 2001 / Comparative study of biphasic calcium phosphate ceramics impregnated with rhBMP-2 as bone substitutes / J Biomed Mater Res 54 : 129 ~ 138
Aldinger G / 1991 / Bone morphogenetic protein: a review / Int Orthop 15 : 169 ~ 177
Gao TJ / 1996 / Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, a
Hiraki Y / 1991 / Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1
Jovanovic SA / 2007 / Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects / Clin Oral Implants Res 18 : 224 ~
Aldinger G / 1991 / Bone morphogenetic protein: a review / Int Orthop 15 : 169 ~ 177
Gao TJ / 1996 / Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, a
Hiraki Y / 1991 / Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1
Jovanovic SA / 2007 / Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects / Clin Oral Implants Res 18 : 224 ~
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