지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: In dental or orthopedic surgery, bone substitutes are inserted with implants to promote osteogenesis and enhance osseointegration. The purpose of this research was to evaluate the efficacy of rhBMP-2 (recombinant human bone morphogenetic protein-2) loaded hydrogel composite for bone formation around dental implant in minipig mandible bone defect models. Methods: We made bone defects with a diameter of 4mm in minipig mandibles and inserted implants of the same size, to mimic the cases of inserting the screws in the bone defect or poor-quality bone. The rhBMP-2 (300 μg) loaded hydrogel composite (0.5 cc) inserted in the bone defect with the implant in the rhBMP-2 group. After 4 weeks, the mandibles were harvested to evaluate the new bone mass around implants using plain radiographs, micro-CT, and histology. Results: The micro-CT analysis result showed that the quantity of new bone generation around the implant in the rhBMP-2 group was greater than that in the other groups. Comparing the ratios of bone to implant area in three groups by histology, the amount of newly formed bone in the rhBMP-2 group was the most. Conclusion: The rhBMP-2 loaded hydrogel composite promotes osteogenesis around dental implant in minipig mandible bone defect, and enhance osseointegration between the dental implant and host bone.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
김지범 / 2015 / Demineralized Bone Matrix Injection in Consolidation Phase Enhances Bone Regeneration in Distraction Osteogenesis via Endochondral Bone Formation / Clinics in Orthopedic Surgery 7(3):383~391
Laurencin C / 2006 / Bone graft substitutes / Expert Rev Med Devices 3(1):49~57
이명진 / 2010 / Effect of Hydroxyapatite on Bone Integration in a Rabbit Tibial Defect Model / Clinics in Orthopedic Surgery 2(2):90~97
Urist MR / 1965 / Bone : formation by autoinduction / Science 150(3698):893~899
Schmitt JP / 2016 / Long-segment fusion for adult spinal deformity correction using low-dose recombinant human bone morphogenetic protein-2 : a retrospective review of fusion rates / Neurosurgery 79(2):212~221
Laurencin C / 2006 / Bone graft substitutes / Expert Rev Med Devices 3(1):49~57
이명진 / 2010 / Effect of Hydroxyapatite on Bone Integration in a Rabbit Tibial Defect Model / Clinics in Orthopedic Surgery 2(2):90~97
Urist MR / 1965 / Bone : formation by autoinduction / Science 150(3698):893~899
Schmitt JP / 2016 / Long-segment fusion for adult spinal deformity correction using low-dose recombinant human bone morphogenetic protein-2 : a retrospective review of fusion rates / Neurosurgery 79(2):212~221
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